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Alzheimer's Imaging Consortium

Saturday, July 13, 2013
8:25 a.m.-5 p.m.
Presented by the ISTAART Neuroimaging Professional Interest Area
Boston Convention & Exhibition Center, 210ABC



Overview Continuing Medical Education
Target audience Accreditation statement
Learning objectives Credit designation
Schedule & Speakers Disclosure of conflicts of interest



Gil Rabinovici, Chair, University of California, San Francisco, United States 
Christopher RoweChair, Austin Health, Melbourne, Australia

The Alzheimer's Imaging Consortium (AIC) pre-conference will focus on the clinical application and methodological development of neuroimaging (MRI, PET, SPECT, CT and others) to Alzheimer's disease, other dementias and normal brain aging. The meeting will consist of invited speakers, as well as oral and poster presentations from submitted abstracts. Presentations from young scientists and interactive discussion will be encouraged. The world's leading imaging and non-imaging researchers will discuss topics such as:

This event is organized by the ISTAART Neuroimaging Professional Interest Area.

Target audience

All researchers and clinicians involved in the care of or research on individuals with memory or other cognitive complaints, including but not limited to neurologists, psychiatrists, radiologists, geriatricians and neuropsychologists; as well as researchers, industry and regulatory agencies stakeholders; and others involved in the use of imaging techniques in the study of Alzheimer's disease, related disorders and normal aging.

Learning objectives

At the end of this educational activity, attendees should be able to:

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Schedule and Speakers



8:25 a.m.


8:30-9:45 a.m.

IC-O1 Imaging Populations at Genetic Risk for Alzheimer's Disease


IC-O1-01 Presymptomatic Functional Brain Changes in PS1 E280A Mutation Carriers Compared to Other Biomarkers: Pilot Data From the Alzheimer's Prevention Initiative Biomarker Project



Adam Fleisher, Kewei Chen, Yakeel Quiroz, Laura Jakimovich, Madelyn Gutierrez, Jessica Langbaum, Auttawut Roontiva, Pradeep Thiyyagura, Ji Luo, Xiaofen Liu, Wendy Lee, Napatkamon Ayutyanont, Stephanie Parks, Claudia Munoz, Sonia Moreno, Natalia Acosta-Baena, Margarita Giraldo, Pierre Tariot, Francisco Lopera, Eric Reiman


IC-O1-02 Are Early Atrophy Patterns in Autosomal Dominant Familial Alzheimer's Disease Gene Dependent?



Kirsi Kinnunen, Natalie Ryan, David Cash, António Bastos Leite, Sarah Finnegan, Manuel Cardoso, Kelvin Leung, Marc Modat, Tammie Benzinger, Clifford Jack, Daniel Marcus, Marcus Raichle, Paul Thompson, John Ringman, Bernardino Ghetti, Stephen Salloway, Reisa Sperling, Peter Schofield, Colin Masters, Richard Mayeux, Ralph Martins, Michael Weiner, Randall Bateman, Alison Goate, Anne Fagan, Nigel Cairns, Virginia Buckles, John Morris, Martin Rossor, Sebastien Ourselin, Nick Fox


IC-O1-03 Hippocampal Transcriptome-Guided Gene-Gene Interaction of Memory Phenotype in MCI and Alzheimer’s Disease



Jingwen Yan, Sungeun Kim, Kwangsik Nho, Rui Chen, Shannon Risacher, Jason Moore, Andrew Saykin, Li Shen


IC-O1-04 Reduced Amyloid Deposition and Greater Hypometabolism in APOE-?4–Positive People with Alzheimer’s Disease



Manja Lehmann, Pia Ghosh, Cindee Madison, Anna Karydas, Giovanni Coppola, Bruce Miller, William Jagust, Gil Rabinovici


IC-O1-05 APOE-e4 is Associated With Increased Hippocampal Atrophy Rates in Alzheimer's Disease



Emily Manning, Josephine Barnes, David Cash, Jonathan Bartlett, Kelvin Leung, Sebastien Ourselin, Nick Fox


IC-O1-05 APOE-ε4 is Associated With Increased Hippocampal Atrophy Rates in Alzheimer's Disease



Emily Manning, Josephine Barnes, David Cash, Jonathan Bartlett, Kelvin Leung, Sebastien Ourselin, Nick Fox

9:45-10:15 a.m.

PL-01 Brain Imaging in Preclinical Study and Prevention of Alzheimer's Disease?

Eric M. Reiman, Banner Alzheimer's Institute, Phoenix, Ariz., United States

10:15–10:30 a.m.



10:30–11 a.m.

PL-02 Developing a Translational Toolbox for Parkinson Disease: The Parkinson Progression Marker Initiative

Kenneth Marek, The Institute for Neurodegenerative Disorders, New Haven, Conn., United States

11a.m.-12:30 p.m.

IC-02 Normal Aging and Early Detection of Alzheimer's Disease


IC-O2-01 How Do We Define Amyloid Positivity in an Asymptomatic Population? Comparison of CSF, Quantitative PET and Clinical PET Examinations



Brian Rubin, Yi Su, Jonathan McConathy, Tyler Blazey, Rosana Ponisio, Jin Weng, Russ Hornbeck, Anne Fagan, Chengjie Xiong, John Morris, Tammie Benzinger


IC-O2-02 Detecting Cognitive Evidence of Preclinical Alzheimer's Disease



Dorene Rentz, Trey Hedden, Elizabeth Mormino, Rebecca Amariglio, John Becker, Aaron Schultz, Gad Marshall, Reisa Sperling, Keith Johnson


IC-O2-03 The Effects of Aging on Whole Brain Functional Connectivity



Matthew Brier, Jewell Thomas, Liang Wang, Tammie Benzinger, John Morris, Beau Ances


IC-O2-04 Association between Regional Task-Free Fmri Synchrony and AD Imaging Biomarkers in Cognitively Normal Subjects



Prashanthi Vemuri, David Thomas Jones, Jeffrey L Gunter, Scott A Przybelski, Brian E Gregg, Mary M Machulda, Mathew L Senjem, Val J. Lowe, David S Knopman, Ronald C Petersen, Clifford R Jack


IC-O2-05 Development of White Matter Lesions is Preceded by Changes in Normal-Appearing White Matter



Marius de Groot, Benjamin Verhaaren, Renske de Boer, Stefan Klein, Albert Hofman, Aad van der Lugt, Mohammad Ikram, Wiro Niessen, Meike Vernooij


IC-O2-06 Perfusion and Structural MRI Correlates of Brain Amyloidosis in Early MCI



Duygu Tosun, Michael Weiner


12:30-2:30 p.m.

Lunch and Poster Viewing/Poster Judging
12:30-1:30 p.m. - Odd poster numbers
1:30-2:30 p.m. - Even poster numbers

2:30-3:45 p.m.

IC-O3 Emerging Techniques


IC-O3-01 The Centiloid Scale: Standardization of Amyloid Imaging Measures



Christopher Rowe, William Klunk, Robert Koeppe, William Jagust, Michael Pontecorvo, Michael Devous, Marybeth Howlett, Daniel Skovronsky, Keith Johnson, Julie Price, Chet Mathis, Mark Mintun


IC-O3-02 Plaque-Binding Magnetic Nanoparticles for Early Diagnosis of Alzheimer's Disease by Magnetic Resonance Imaging (MRI)



Kwok Kin Cheng, Larry Baum


IC-O3-03 The Relationship Between Hippocampal Atrophy and Neuropathology Markers: A 7T MRI Study



Liana Apostolova, Sona Babakchanian, Somme Johanne, Hedieh Honarpisheh, Kristy Hwang, Kristina Biado, Spencer Tung, Andrew Frew, Jeffry Alger, Jonathan Wisco, Stephen Schettler, Chris Zarow, Harry Vinters, Paul Thompson


IC-O3-04 In-Vivo Characterization of Glutamatergic Vulnerability in Behavioral Variant FTD: An [11C]ABP688 PET/ VBM /DBM Study



Antoine Leuzy, Jared Rowley, Laksanun Cheewakriengkrai, Monica Shin, Seqian Wang, Maxime Parent, Eduardo Zimmer, Marina Dauar, Pedro Rosa-Neto, Serge Gauthier


IC-O3-05 Task-Free fMRI in Clinical Trials: Selection of Covariates and Numeric Endpoints



Adam Schwarz, Basile Pinsard, Vincent Perlbarg, Yuefeng Lu, Lea Marais, Derek Hill, Jean-Francois Mangin, Adam Schwarz

3:45-4:15 p.m.

Panel Discussion—The Role of Neuroimaging in AD Drug Development: Lessons from Recent Clinical Trials

Nick Fox, Alzheimer’s Research UK, London, United Kingdom

Paul Aisen, University of California, La Jolla, Calif., United States
Maria Carillo, Alzheimer’s Association, Chicago, Ill., United States
Howard Feldman, Yale School of Medicine, New Haven, Conn., United States
Eric Karran, Alzheimer’s Research UK, London, United Kingdom
Philip Scheltens, VU University Medical Center, Amsterdam, the Netherlands
Eric Siemers, Eli Lilly & Company, Indianapolis, Ind. United States
Reisa Sperling, Brigham and Women's Hospital and Massachusetts General Hospital, Boston, Mass., United States

4:15-4:45 p.m.

Neuroimaging Prize Announcements/Presentations

4:45-5 p.m.

Best poster and oral announcement





(the application process is now closed)

A limited number of fellowships (in the form of complimentary AIC registration) are available for young researchers who submit an abstract. Awardees will be chosen based on the anonymous reviewers' ratings of their oral or poster abstract and financial need. Additionally, the best oral and poster presentation among this group will be awarded a $500 prize each.

Continuing Medical Education

This activity is jointly sponsored by the Postgraduate Institute for Medicine (PIM) and the Alzheimer's Association.
Description: PIM Postgraduate Institute for Medicine
Scientific sessions are not supported by any commercial entity.

Accreditation statement

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Postgraduate Institute for Medicine and the Alzheimer's Association. The Postgraduate Institute for Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit designation

The Postgraduate Institute for Medicine designates this live activity for a maximum of 5.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of conflicts of interest

Postgraduate Institute for Medicine (PIM) requires instructors, planners, managers and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to PIM policy. The existence or absence of COI for everyone in a position to control content will be disclosed to participants prior to the start of each activity.

AAIC 2013 program

View the 2013 schedule and conference program.

Registered attendees have exclusive access to the 2013 AAIC mobile app with full speaker and session listings as well as abstract content. Attendees can email for download instructions.


2013 Imaging Consortium Sponsors

General Electic Health Care