Educational Workshop: The Basics of Fluid Biomarkers in Alzheimer’s Disease
Friday, July 14, 2017
8 a.m. – 5 p.m.
The fluid biomarkers field for Alzheimer’s disease and related disorders is rapidly expanding. The purpose of this workshop is to provide research investigators, clinicians, residents, fellows and graduate and postgraduate students with an in-depth understanding of the fundamental principles, inherent limitations and clinical and research applications of the most common biomarkers used in Alzheimer's disease (AD) and found in cerebrospinal fluid (CSF) and blood. This workshop will include the fundamentals of CSF physiology, basics of neurochemistry, technical issues of sample collection, storage, analysis methods, quality control and regulatory issues. It will also cover the latest in cutting edge biomarker technology including blood-based biomarkers with the current understanding of how biomarkers track the progression in AD and their use in other dementias. Lectures will be followed by interactive sessions to ensure that participants gain in depth understanding of the proper use of fluid biomarkers.
This workshop is organized by leading scientists in the field and by the Alzheimer’s Association Global Biomarkers Standardization Consortia (GBSC) and the ISTAART Biofluid Based Biomarkers PIA.
Welcome / Introduction
Topic 1: Introduction to CSF Physiology
Topic 2: Basic Neurochemical Analysis
Topic 3: Analytical Techniques for Biomarker Measurement
Topic 4: Operational Issues (Sample Collection, LP’s, Storage)
Topic 5: Standardization, Quality Control and Regulatory Issues for Fluid Biomarkers
Piotr Lewczuk and Robert Dean
Topic 6: Current Clinical Use of Fluid Biomarkers for AD & Differential Diagnosis in Dementia (Case-based approach)
Piotr Lewczuk and Jonathan Schott
Topic 7: Emerging Clinical Use of Fluid Biomarkers for AD & Dementia
Topic 8: Cutting Edge Techniques Including Blood Based Biomarkers
Review and quiz