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Mild Alzheimer’s Clinical Research Study – Cleveland, OH

Do you or someone you know have mild Alzheimer’s disease? Then you may be interested in the DAYBREAK-ALZ clinical research study. We’re looking for volunteers to help us find out whether an investigational medication will slow the rate of cognition and functional decline.

About DAYBREAK-ALZ Mild Alzheimer’s Clinical Research Study

You may be suitable if you are:

  • Aged between 55 to 85 years old
  • Have experienced a gradual loss of memory over the last 6 months OR Have been diagnosed with mild Alzheimer’s disease


They will be a close friend, relative or partner who can:

  • Attend all your clinic visits with you
  • Answer questions over the telephone

For more information or to sign up for this study click here

Cyndi Hovland-Scafe, PhD, Assistant Professor at The School of Social Work at Cleveland State University, and Annette Franklin, PhD, Adjunct Faculty at Cleveland State University are exploring African-American caregivers’ experiences with preparedness of the death of a family member from a dementia-related diagnosis. It is hoped that the results of this study will help professionals to understand better the physical, emotional, social and spiritual needs of family members caring for a loved one at the end of his or her life.

  • Did you provide care to a family member age 65 or older who died from dementia within the past 6-18 months?

If so, would you be willing to share your experiences? To participate in this study, myself or Dr. Annette Franklin would meet with you at the Alzheimer’s Association-Cleveland Area Chapter or another convenient location for a 60-90 minute interview. In exchange for your participation, you will receive $30. For more information please contact:

Cyndi Hovland-Scafe
(216) 687-4553

Annette Franklin
(814) 882-2204

Would you like to help shape the future of Alzheimer’s management? 
If so, we would like to talk to you.

At Cleveland State University, we are doing research focused on helping people with Alzheimer’s Disease remain independent. We are seeking research participants for an interview study. The purpose of this study is to help us develop new computer technologies that can help people with Alzheimer’s manage daily activities. We would like to interview people over age 65 with dementia/Alzheimer’s, and a caregiver: the family member or friend on whom the elder depends on most for help and support. The interview will be like a conversation and will contain questions about background and life experiences. Responses to the interview will tell us how to tailor new technologies to be most helpful. The interviews will take about 30-45 minutes each. As a thank you, we will provide a $20 gift card to each of you at the end of your interview. To volunteer, please contact Dr. Linda Francis, using the information below. Leave a message with your name and phone number, and someone from the study will return your call as soon as possible.

Thank you!

Dr. Linda Francis, PhD
Cleveland State University
(216) 687-4510


The Cleveland Clinic Lou Ruvo Center for Brain Health at Main Campus  is currently looking for healthy older adults between the ages of 60 and 80 with or without a family history of Alzheimer’s Disease for a new research study.

The study will look at the effects of Donepezil HCL (Aricept) on Task-Activated fMRI brain activation. Participation will last approximately 7-8 months including 9 clinic visits and will involve 2 MRI scans, genetic testing, and evaluations of memory function.

Financial compensation will be provided.
For more information, please call:
Or email:

AMBAR Study  (Alzheimer management by albumin replacement)

The Cleveland Clinic Lou Ruvo Center for Brain Health at Main Campus is conducting the AMBAR research study.  This trial is looking at the use of albumin replacement as a treatment for Alzheimer's Disease.  Albumin is a naturally-occurring protein found in blood plasma that serves many functions.  The AMBAR study will use plasma exchange to separate and remove plasma from blood.  Albumin will replace the plasma that is removed.

This is an approximately 14 month study with weekly visits for 10 weeks, then monthly visits for 12 months.

  • You may be eligible to take part in this study if you:
  • Are between 55 to 85 years old
  • Have been diagnosed with mild-to-moderate Alzheimer's disease
  • Have received a stable dose of memory medication for the past three months
  • Have an available and reliable caregiver

For more information, please call:
Or email:

Interested In Boxing/MMA Research?

Need brain healthy volunteers to participate as a control group in a research study investigating the effects of cumulative head trauma in professional fighters at the Cleveland Clinic Lou Ruvo Center for Brain Health at Main Campus

Participants should be:

  • Men or women who are at the age of 18+
  • have not engaged in sports such as  football, soccer, boxing, wrestling, martial arts, hockey, rodeo at the high school level or above
  • have not experienced a concussion
  • Willing to participate once a year for at least 4 years

Participants will be asked to undergo a series of tests which include brain MRI scan, neurological examination, computerized cognitive testing, questionnaires regarding demographics, health history, mood and sleep,  and provide a blood sample once a year for 4 consecutive years.

Participants will be compensated $100.00 at each visit

For more information, please call:
Or email:


Understanding dementia: The effects of supportive services on the perceived stress of caregivers.

The purpose of this study is to analyze and compare the supportive services available to caregivers of individuals with dementia to determine which service is associated with the lowest levels of stress. This will allow for the cultivation of a better understanding of the most effective services and may help caregivers to assess their mental health needs and find the most effective form of supportive service. Caregivers, over the age of 18, of individuals with dementia are eligible to participate in the study. Participation and responses will be held strictly confidential. Participants will not be asked to put any identification on the questionnaires however with any internet survey there is no way to guarantee absolute anonymity.

If you are a caregiver for a person with dementia, please complete the anonymous survey at the following link:


The Cleveland Clinic Lou Ruvo Center for Brain Health is currently looking for healthy older adults between the ages of 60 and 80 with or without a family history of Alzheimer’s Disease for a new research study.

The study will look at the effects of Donepezil HCL (Aricept) on Task-Activated fMRI brain activation. Participation will last approximately 7-8 months including 9 clinic visits and will involve 2 MRI scans, genetic testing, and evaluations of memory function.

Financial compensation will be provided.

For more information, please call:
Or email:

Phase II, Multicenter, Sixteen-Week, Randomized, Double Blind, Placebo-Controlled Evaluation of the Efficacy, Tolerability and Safety of Memantine Hydrochloride on Enhancing the Cognitive Abilities of Adolescents and Young Adults with Down Syndrome- Study Subjects Wanted

A team of medical doctors and psychologists at the Case Western Reserve University, University Hospitals, and the Cleveland Clinic is investigating the effects of memantine on individuals with Down syndrome who are between the ages 15 and 32. Memantine is a medication FDA-approved for the treatment of Alzheimer's disease, but it is not approved for use in persons with Down syndrome. This study was designed to examine whether or not this medication is safe and if it can improve memory and learning skills in adolescents and young adults with Down syndrome.

This study requires the participant and his or her primary caregiver to complete five to seven outpatient visits to University Hospitals in Cleveland, Ohio. Psychological and medical tests will take place during the visits. The tests, medication, and medical care related to the study are provided free of charge. Parking will be validated, and mileage can be reimbursed for those traveling 20 miles or more to come to the study.

If you, or someone you know, would be interested and meet the following requirements:

  • 15-32 years of age
  • medically diagnosed with Down syndrome
  • in good general health and not pregnant
  • able to swallow medicine capsules (crushing of capsules will not be permitted)
  • have a reliable caregiver or family member who agrees to come with the participant to all visits, provide information about the participant, and ensure compliance with the medication schedule
  • know enough English to be capable of reliably completing study tests

The study Principal Investigator is Alberto Costa, MD, PhD
Department of Pediatrics, Division of Pediatric Neurology
Case Western Reserve University and University Hospitals

For more information, please call or E-mail the study coordinator, Ms. Melissa Stasko (216-844-7281,

Alzheimer's Disease: NeuroAD Clinical Trial

Patients may qualify for this study if they:

  • Are 60 to 90 years old
  • Have a diagnosis of dementia due to probable
  • Alzheimer's disease (AD)
  • Have a study partner willing to accompany them to all study visits and answer questions regarding the patients condition.
  • Are on a stable dose of donepezil, rivastigmine or galantamine for at least 90 days before screening and throughout the study.

The study doctor will check for other medical conditions or reasons that might prevent you from participating in the study.

The NeuroAD Study is testing a non-invasive therapeutic system designed to improve cognitive functioning through magnetic stimulation to targeted areas of the brain. In addition, cognitive training is done simultaneously using a interactive video screen. It is a 15 week program consisting of daily 1 hour appointments, five days a week for 6 weeks; two screening visits including an MRI; and two follow up visits, one at 7 weeks and the other at 12 weeks.

If you are interested in participating or would like additional information, please contact the study coordinator, Christine Whitman, RN.

216.227.2438 or

Families Affected by Dementia

Do you have a relative who is 60 years or older with dementia or age-related memory impairment?

Are you a live-in, unpaid caregiver for this family member?

If so, you may be eligible to participate in a telephone survey. Upon completion of the survey, you will be compensated $40 for your time.

Call the Aging Family Project University of Miami
(305) 284-5455 Dr. Amy G. Weisman de Mamani


Have increasing forgetfulness or difficulty thinking, or concerned you may have Alzheimer’s disease?

Current available medications help manage symptoms but do not slow the course of Alzheimer’s disease.  Through ongoing clinical research, doctors evaluate study drugs that may control symptoms and, may possibly help with disease management.

We are evaluating the effectiveness and safety of an oral study drug that may help slow or stop the progression of Alzheimer’s Disease.

To be considered for study participation, you must:

  • Be 50 to 85 years old
  • Have symptoms of worsening memory or thinking problems of the past year.
  • Have a partner or caregiver willing to accompany  you to study visits and help you follow study requirements
  • Other eligibility requirements apply.

All study-related drugs and care will be provided at no cost. 
This study is being conducted at Insight Clinical Trials LLC. 

Please contact Elisa @ (216) 832-6606 or for further information

Cleveland Clinic Center for Brain Health :
Aging and Neurodegeneration Biobank

The Cleveland Clinic Lou Ruvo Center for Brain Health at Main Campus is creating a biobank under the direction of Dr. James Leverenz and Lynn Bekris, PhD. The purpose of the biobank is to facilitate research on aging, including Alzheimer’s disease and Parkinson’s disease, by storing biospecimens (blood, CSF etc.) and corresponding clinical information which can be quickly and readily used by investigators.

We are looking for participants diagnosed with a neurodegenerative disease or those who are healthy to participate by donating blood to be stored in the biobank. If you choose to participate in this study, you will also be asked to undergo testing of your thinking and memory skills.  We will confirm additional information such as family history and health status, so it can be linked to the samples you provide.  If you are interested in donating other biospecimens such as cerebrospinal fluid, it can be discussed further at the initial visit. Participation in the study will take approximately 2-3 hours. 

For more information, please call:
Or email:

Axovant Visual Hallucinations

The Cleveland Clinic Center for Brain Health at Main Campus is recruiting participants for a clinical study to evaluate the investigational medication Nelotanserin in subjects with frequent visual hallucinations due to dementia of Lewy bodies or Parkinson’s disease dementia.  There is no medication currently approved for visual hallucinations in dementia patients.

This is an 18 week study with 8 study visits

  • Patients may qualify for this study if they:
  • Are 50 to 85 years old
  • Currently experiencing problems with hallucinations
  • Have a study partner willing to accompany them to all study visits and answer questions regarding the patient’s condition
  • if taking medications for memory/behavior problems or visual hallucinations, must be on a stable dose for at least 30 days prior to study screening

Research Study seeks interested Individuals at least 70 years old with no memory problems or with mild to moderate memory problems are invited to take part in a research study.*

  • The study involves 2 visits spaced 12 months apart.
  • Each visit will last approximately 2 hours and will involve questions about you and your health.
  • There are no invasive procedures or medications.
  • Participants will receive a stipend after completing each study visit.
  • Study participants need to be able to read and speak English and complete written questionnaires.

    *This includes those diagnosed with Mild Cognitive Impairment
    or early Alzheimer’s disease.

Drs. Kathleen Smyth and Martha Sajatovic of the Neurological Outcomes Center are the study’s Principal Investigators. The goal of this study is to find the best way to measure the effects of future treatments to improve physical and mental function of older adults.

The study is funded by the National Institutes of Health.

For more information please contact
Nancy 216-368-2668

Alzheimer’s Disease & Cataract Removal Research Study

University Hospitals Case Medical Center, the MetroHealth Medical System, and Case Western Reserve University are now enrolling patients in a new, 5-year research study sponsored by the National Institutes of Health. 

In the study, we will learn more about how cataract removal impacts Alzheimer’s disease patients in their daily activities, their quality of life, their mood, and their performance on memory, cognitive, and visual tasks.

The duration of the study for each Participant will be approximately 6 months.  All study Participants will first be screened to determine if they are eligible and then randomly selected into one of two groups: Group A (immediate surgery group), or Group B (delayed surgery group).  Group A will have their cataract surgery within 1 month of enrolling in the study.  Group B will be asked to delay their cataract surgery for 6 months.

To be eligible, you must be at least 50 years or older, have a diagnosis of Alzheimer’s disease, have cataracts in both eyes, and know someone who can act as your “study partner.” 

To learn more about this study, please contact the University Hospitals Study Coordinator, Tatiana Riedel at 216-368-6465, (e-mail, or the MetroHealth Study Coordinator, Alicia O’Brien at 216-778-2461 (e-mail

Participants needed for
Center for Brain Health Study

Are you generally healthy, between the ages of 60 and 85, and have had a family member diagnosed with Alzheimer’s Disease? If so, you may be eligible for a new study being conducted at the Lou Ruvo Cleveland Clinic Center for Brain Health.

Please download the following 2 PDFs for more information about the study and how to participate 

    Click Here for a printable flyer         Click Here for  printable Brochure




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Formed in 1980, the Alzheimer's Association is the world's leading voluntary health organization in Alzheimer's care, support and research.