Coming from south of the Denver Tech Center:

Take I-25 north toward Denver.
Take the exit toward CO-88 W/E Belleview Ave.
Keep right at the fork, follow the signs for CO-88 W/ Quebec and merge onto CO-88 W/E Belleview Ave.
Take your first left onto S. Syracuse St.
You will see the Denver Marriott Tech Center 4900 S. Syracuse St. on the left.

Coming from north of the Denver Tech Center:

Take I-25 south toward Colorado Springs
Take exit 199 for Belleview Ave/CO-88.
Turn left onto E. Belleview Ave./S. Quebec St.
Take your first left onto S. Syracuse St.
You will see Denver Marriott Tech Center 4900 S. Syracuse St. on the left.