Research Update: New Findings on Cholesterol and Alzheimers Risk

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New Findings on Relationship between Cholesterol and Alzheimers Risk

Results of a study published in the Nov. 10 online issue of Neurology suggest that large decreases in cholesterol levels in old age could be a predictor of developing Alzheimer's disease. Contrary to what has been found in other research, the findings in this study, which was funded in part by the Alzheimer's Association, suggest that cholesterol level in mid-life may not be linked to later development of Alzheimer's disease.

Based on what we know now, people should still control their cholesterol levels in mid-life. In fact, it is important to keep your cholesterol at healthy levels throughout your life. The authors of the newly published study say, "Cholesterol should still be monitored and treated through diet, exercise and medication for cardiovascular and overall health."

This article does not solve the issue of cholesterol's role in Alzheimer's disease risk, but it does add intriguing data to a complex, ongoing discussion. This article presents somewhat unexpected findings, and we need more research to clarify the issue.

We need long-term observational studies in Alzheimer's disease — like the Framingham Study in heart disease — to learn more about possible risk factors for Alzheimer's over the course of lives and generations.
We need controlled clinical trials to know for certain if changing lifestyle or intervening with medicine can reduce the risk of Alzheimer's or change the course of the disease.

ALZHEIMER'S ASSOCIATION INVOLVEMENT

One of the study's co-authors received the Alzheimer's Association Zenith Award, which provided some of the funding for this research. The Alzheimer's Association has been involved in nearly every major advancement in Alzheimer research since the 1980s and is a leader in the global fight for a world without Alzheimer's.

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The Alzheimer's Association is the leading voluntary health organization in Alzheimer care, support and research. Our mission is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

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