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Funded Studies 2005-2013


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Funded Studies: 2005


BELGIUM

Christine Van Broeckhoven, Ph.D.
University of Antwerp
Antwerp, Belgium
Frontotemporal Dementia With Ubiquitin-Positive Neuronal Inclusions (FTD-U)
Zenith Fellows Award—$247,350 over two years
Supported through the generosity of the Zenith Fellows

CANADA

Gabrielle L. Boulianne, Ph.D.
The Hospital for Sick Children
Toronto, Ontario, Canada
Presenilins, Calcium Homeostasis and Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Richard E. Brown, Ph.D.
Dalhousie University
Halifax, Nova Scotia, Canada
Neurobehavioral Analysis of a Double Transgenic Mouse Model of Alzheimer's Disease
Investigator-Initiated Research Grant—$237,600 over three years

Dusica Maysinger, Ph.D.
McGill University
Montreal, Québec, Canada
Mechanisms of Nonsteroidal Therapies to Reduce the Risk of Alzheimer's Disease in Menopause
Investigator-Initiated Research Grant—$237,000 over three years

FRANCE

Jean-Pierre Changeux, Ph.D.
Institut Pasteur
Paris, France
Autoantibodies to Nicotinic Receptors in Alzheimer's Disease
Investigator-Initiated Research Grant—$178,420 over three years
Supported through the generosity of Rally for Research

GERMANY

Michael E. Calhoun, Ph.D.
Hertie-Institute for Clinical Brain Research
Tuebingen, Germany
Relational Memory and Learning-Related Gene Induction in Alzheimer Mouse Models
Investigator-Initiated Research Grant—$237,282 over three years

ITALY

Fabrizio Gardoni, Ph.D.
University of Milano
Milano, Italy
Molecular Interactors for Alpha-Secretase: Physio-Pathological Role
New Investigator Research Grant—$100,000 over two years

NETHERLANDS

Corneila M. Van Duijn, Ph.D.
Erasmus MC
Rotterdam, Netherlands
In Search of Genes for Alzheimer's Disease in a Genetically Isolated Population
Investigator-Initiated Research Grant—$239,850 over three years
Supported through the generosity of Rally for Research

SWEDEN

Hans Basun, M.D., Ph.D.
Uppsala University
Uppsala, Sweden
Amyloid in Brain, CSF and Plasma in Alzheimer Patients: One-Year Followup
Zenith Fellows Award—$246,400 over two years
Supported through the generosity of the Zenith Fellows

UNITED STATES

Alabama

Ling Li, Ph.D.
University of Alabama at Birmingham
Birmingham, Alabama
Excess Intake of Dietary Sugars in the Development of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

California

Marion S. Buckwalter, M.D., Ph.D.
Stanford University
Stanford, California
Altering TGF-Beta Signaling to Induce Neural Stem Cell Proliferation in Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Bruce L. Kagan, M.D., Ph.D.
University of California at Los Angeles
Los Angeles, California
Beta-Amyloid Channel Blockers
Investigator-Initiated Research Grant—$239,454 over three years
Supported through the generosity of Scott and Mary Ferguson

David E. Kang, Ph.D.
University of California at San Diego
La Jolla, California
Role of Presenilins in Neurodegeneration and Tau Pathology
Investigator-Initiated Research Grant—$240,000 over three years

Frank M. LaFerla, Ph.D.
University of California at Irvine
Irvine, California
Learning and Memory Deficits in a Mouse Model With Plaques and Tangles
Zenith Fellows Award—$250,000 over two years
Supported through the generosity of the Zenith Fellows

Lene Levy-Storms, Ph.D., M.P.H.
University of California at Los Angeles
Los Angeles, California
Improving Staff Communication With Nursing Home Residents During Mealtime
Investigator-Initiated Research Grant—$239,976 over three years

Jeanne F. Loring, Ph.D.
The Burnham Institute
La Jolla, California
Stem Cells as Delivery Vehicles to Target Amyloid Plaques and Tangles
Investigator-Initiated Research Grant—$235,000 over three years

Ira T. Lott, M.D.
University of California at Irvine
Orange, California
Diagnosis of Alzheimer's Disease in Down Syndrome by Telemedicine
Senator Mark Hatfield Award for Clinical Research in Alzheimer's Disease—237,367 over three years

William C. Mobley, M.D. Ph.D.
Stanford University
Stanford, California
Role of APP in NGF Transport in Down Syndrome and Alzheimer's Disease
Investigator-Initiated Research Grant—$239,704 over three years

Nidhi Mahendra, Ph.D.
California State University
Hayward, California
Computer-Based Cognitive Interventions for Persons with Alzheimer's Disease
Everyday Technologies for Alzheimer Care—$198,624 over three years

David B. Reuben, M.D.
University of California at Los Angeles
Los Angeles, California
Practice Redesign and Partnership to Improve Quality of Dementia Care
Investigator-Initiated Research Grant—$239,587 over three years

David V. Schaffer, Ph.D.
University of California at Berkeley
Berkeley, California
Evolution of AAV Vectors for Efficient Gene Delivery to Astrocytes
New Investigator Research Grant—$100,000 over two years

Gia R. Shurgot, Ph.D.
University of Southern California
Los Angeles, California
Sociocultural Influences on the Health of Latino Dementia Caregivers
New Investigator Research Grant—$99,928 over two years

Yi E. Sun, Ph.D.
University of California at Los Angeles
Los Angeles, California
Adult Neurogenesis in Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Jun Ming Wang, Ph.D.
University of Southern California
Los Angeles, California
Differential Regulation of ApoE Expression by ER Alpha and Beta
New Investigator Research Grant—$100,000 over two years

Tony Wyss-Coray, Ph.D.
Stanford University
Stanford, California
Role of Systemic Neurotrophin Deficiency in Alzheimer Pathogenesis
Zenith Fellows Award—$250,000 over two years
Supported through the generosity of the Zenith Fellows

Liqin Zhao, Ph.D.
University of Southern California
Los Angeles, California
Estrogen Receptor Subtype-Selective Phytoestrogens for Prevention of Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Colorado

Victoria S. Pelak, M.D.
University of Colorado
Aurora, Colorado
Virtual Reality Assessment of Visuospatial Disorientation in Alzheimer's
Investigator-Initiated Research Grant--$240,000 over three years

Connecticut

Richard A. Flavell, Ph.D.
Yale University
New Haven, Connecticut
An Inducible Mouse to Elucidate the Role of Immunity/Inflammation in Alzheimer's Disease
Investigator-Initiated Research Grant—$237,772 over three years

Keith A. Hawkins, Psy.D.
Yale University
New Haven, Connecticut
Neuropsychological Norms for Elderly African-Americans
Investigator-Initiated Research Grant—$239,992 over three years

John P. Seibyl, M.D.
Institute for Neurodegenerative Disorders
New Haven, Connecticut
Development of 123-I IMPY as a Biomarker for Alzheimer Imaging
Investigator-Initiated Research Grant-$237,563 over three years

Florida

Pritam Das, Ph.D.
Mayo Clinic Jacksonville
Jacksonville, Florida
Effect of Gamma-Secretase Inhibition on the Anti-Beta-Amyloid Immune Response
New Investigator Research Grant—$99,998 over two years

Todd Eliot Golde, M.D., Ph.D.
Mayo Clinic Jacksonville
Jacksonville, Florida
Novel Animal Models of Amyloid Deposition
Zenith Fellows Award—$250,000 over two years
Supported through the generosity of the Zenith Fellows

Catherine E. Price, Ph.D.
University of Florida
Gainesville, Florida
Non-Cardiac Surgery and Alzheimer's Disease: Cortisol and Cognitive Decline
New Investigator Research Grant—$99,999 over two years

Frank M. Webbe, Ph.D.
Florida Institute of Technology
Melbourne, Florida
PocketPC Technology to Promote Quality of Life for Alzheimer Patients and Caregivers
Everyday Technologies for Alzheimer Care—$199,996 over three years

Illinois

Perry Edelman, Ph.D.
Mather LifeWays Institute on Aging
Evanston, Illinois
Integrating Activity-Focused Quality of Life Assessment into Dementia Care Practice
Investigator-Initiated Research Grant—$238,169 over three years

Chih J. Han, Ph.D.
Northwestern University
Chicago, Illinois
BACE-1 Inducible Knockdown for Alzheimer's Disease Rescue
New Investigator Research Grant—$99,987 over two years

Susan O. McGuire, Ph.D.
Loyola University Medical Center
Maywood, Illinois
C5L2: A Decoy Complement Receptor With Anti-Inflammatory Properties in Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Kulandaivelu S.Vetrivel, Ph.D.
University of Chicago
Chicago, Illinois
Exploring Gamma-Secretase Function in Lipid Raft Membrane Microdomains
New Investigator Research Grant—$100,000 over two years

Indiana

Debomoy K. Lahiri, Ph.D.
Indiana University
Indianapolis, Indiana
Functional Domains of the BACE Promoter: Implication in Alzheimer's Disease
Zenith Fellows Award—$250,000 over two years
Supported through the generosity of the Zenith Fellows

Ruben Vidal, Ph.D.
Indiana University
Indianapolis, Indiana
Biochemical Basis of Phenotypic Variability in Familial Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Kentucky

Suzanne L.Tyas, Ph.D.
University of Kentucky Research Foundation
Lexington, Kentucky
Vascular Risk Factors, Vascular Pathology, and Alzheimer's Disease
New Investigator Research Grant—$99,603 over two years
Supported through the generosity of the National Association of Retired Federal Employees

Louisiana

Chu Chen, Ph.D.
Louisiana State University Health Sciences Center?New Orleans
New Orleans, Louisiana
COX-2 Regulation of Endocannabinoid Signaling in Neurodegeneration
Investigator-Initiated Research Grant—$239,999 over three years

Maryland

Alfredo Kirkwood, Ph.D.
Johns Hopkins University
Baltimore, Maryland
Neurophysiological Analysis of Presenilin Function at the Synapse
Investigator-Initiated Research Grant—$240,000 over three years

Alena Savonenko, Ph.D.
Johns Hopkins University
Baltimore, Maryland
APP-Dependent and Independent Effects of BACE-1 Knockout on Cognition
Investigator-Initiated Research Grant—$240,000 over three years

Massachusetts

Dean M. Hartley, Ph.D.
Brigham and Women's Hospital
Cambridge, Massachusetts
Transglutaminase's Role in Neurodegeneration
Investigator-Initiated Research Grant—$240,000 over three years

Susan L. Mitchell, M.D.
Hebrew Rehabilitation Center for Aged
Boston, Massachusetts
Improving Hospice Care in Advanced Dementia
Investigator-Initiated Research Grant—$190,503 over two years

H. Eugene Stanley, Ph.D.
Boston University
Boston, Massachusetts
Understanding Formation of Neurotoxic Oligomers in Alzheimer's Disease
Zenith Fellows Awards—$250,000 over two years
Supported through the generosity of the Zenith Fellows

Howard L. Weiner, M.D.
Brigham and Women's Hospital
Boston, Massachusetts
Antibody -Independent Clearance of Beta-Amyloid in a Mouse Model of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Michael S. Wolfe, Ph.D.
Brigham and Women's Hospital
Boston, Massachusetts
Inhibitors of Amyloid Production Selective for APP Vis-à-Vis Notch
Investigator-Initiated Research Grant—$240,000 over three years

Michigan

Kim J. Curyto, Ph.D.
Pine Rest Christian Mental Health Services
Grand Rapids, Michigan
Linking Behaviors and Interventions: Impact of a Residential Behavior Program
New Investigator Research Grant—$99,700 over two years

David Loeffler, Ph.D.
William Beaumont Hospital
Royal Oak, Michigan
Alterations in Complement Activation During Alzheimer's Disease Development
Investigator-Initiated Research Grant—$97,036 over one year

Minnesota

Bradley F. Boeve, M.D.
Mayo Clinic Rochester
Rochester, Minnesota
Treatment of Obstructive Sleep Apnea in Patients With Mild Cognitive Impairment (MCI) or Alzheimer's Disease
Investigator-Initiated Research Grant—$239,792 over three years
Supported through the generosity of the Pearson Family in care of the Alzheimer's Association - Minnesota-North Dakota Chapter

Mary M. Machulda, Ph.D.
Mayo Clinic Rochester
Rochester, Minnesota
Functional MRI Activation Patterns in Mild Cognitive Impairment (MCI) Subtypes
New Investigator Research Grant—$100,000 over two years
Supported through the generosity of the Pearson Family in care of the Alzheimer's Association - Minnesota-North Dakota Chapter

Missouri

David M. Holtzman, M.D.
Washington University
St. Louis, Missouri
Effects of Neurotransmitters and Synaptic Activity on Brain ISF Beta-Amyloid
Zenith Fellows Award—$250,000 over two years
Supported by the generosity of the Zenith Fellows

Jody L. Lingbeck, Ph.D.
Washington University
St. Louis, Missouri
LRP-Mediated Intraneuronal Accumulation of Beta-Amyloid
New Investigator Research Grant--$97,088 over two years
Supported through the generosity of Charles and Joanne Knight and the Emerson Electric Company in care of the Alzheimer's Association -- St. Louis Chapter

Heather L. True-Krob, Ph.D.
Washington University
St. Louis, Missouri
Molecular Misreading: Cause or Consequence of Protein Aggregation?
New Investigator Research Grant—$100,000 over two years
Supported through the generosity of Charles and Joanne Knight and the Emerson Electric Company in care of the Alzheimer's Association -- St. Louis Chapter

New York

Rosemary Bakker, M.S.
Weill Medical College of Cornell University
New York, New York
The Alzheimer-Friendly Virtual Home: A Caregiver Home Safety Tool
Investigator-Initiated Research Grant—$240,000 over three years

Adam M. Brickman, Ph.D.
Columbia University
New York, New York
Cognitive Reserve and Structural MRI in Alzheimer's Disease and Mild Cognitive Impairment (MCI)
New Investigator Research Grant—$99,957 over two years
Supported through the generosity of Rally for Research

Luciano D'Adamio, M.D. Ph.D.
Albert Einstein College of Medicine
Bronx, New York
Role of Membrane Proteins in APP Processing and Signaling
Investigator-Initiated Research Grant—$240,000 over three years

Nancy S. Foldi, Ph.D.
Queens College
Flushing, New York
Detecting an Early Response to Donepezil With Measures of Visual Attention
Investigator-Initiated Research Grant—$239,998 over three years
Supported through the generosity of Rally for Research

Cheng-Xin Gong, M.D.
Research Foundation for Mental Hygiene, Inc.
New York State Institute for Basic Research
Staten Island, New York
O-GlcNAcylation and Phosphorylation of Tau protein
Investigator-Initiated Research Grant—$239,910 over three years
Supported through the generosity of the Directors' Fund

Jens Husemann, M.D.
Columbia University
New York, New York
Role of Astrocytes in Beta-Amyloid Metabolism
Investigator-Initiated Research Grant—$240,000 over three years

Kent Kirshenbaum, Ph.D.
New York University
New York, New York
Peptide Mimetic Imaging Agents for Detection of Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Christine Li, Ph.D.
The Research Foundation of City University of New York
New York, New York
Function of APL-1, an APP-Related Protein in C. Elegans
Investigator-Initiated Research Grant—$239,593 over three years

Jose A. Luchsinger, M.D.
Columbia University
New York, New York
Cognition in the IDEATel Diabetes Trial
Investigator-Initiated Research Grant—$239,394 over three years

Jennifer J. Manly, Ph.D.
Columbia University
New York, New York
Health and Cognition Among African-American Women
Investigator-Initiated Research Grant—$240,000 over three years

Mary Sano, Ph.D.
Mount Sinai School of Medicine
Bronx, New York
Randomized Trial of a Nutritional Supplement in Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years
Supported through the generosity of the William and Marian Littleford Foundation

Chunyu Wang, M.D., Ph.D.
Rensselaer Polytechnic Institute
Troy, New York
High-Resolution NMR of ABAD-Abeta Interaction
New Investigator Research Grant—$100,000 over two years

Rong Wang, Ph.D.
Mount Sinai School of Medicine
New York, New York
Biomarkers for Early Detection of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years
Supported through the generosity of the National Association of Retired Federal Employees

Shi Du Yan, M.D.
Columbia University
New York, New York
Role of Mitochondrial Beta-Amyloid in Alzheimer's Disease
Zenith Fellows Award—$250,000 over two years
Supported through the generosity of the Zenith Fellows

New Mexico

Bryce Chackerian, Ph.D.
University of New Mexico
Albuquerque, New Mexico
Vaccines Against Beta-Amyloid Using Conjugated Virus-Like Particles
New Investigator Research Grant—$99,195 over two years

North Carolina

Boyd Davis, Ph.D.
University of North Carolina at Charlotte
Charlotte, North Carolina
Culturally Competent Materials on Communication and Dementia
Investigator-Initiated Research Grant—$237,408 over three years

Yi-Ju Li, Ph.D.
Duke University
Durham, North Carolina
Development of Association Methods for Studying Alzheimer's Disease in African-Americans
Investigator-Initiated Research Grant—$239,696 over three years

Margaret A. Pericak-Vance, Ph.D.
Duke University
Durham, North Carolina
Identifying the Chromosome 12q Gene: Sifting Through the Haystack
Investigator-Initiated Research Grant—$239,792 over three years

Sheryl Zimmerman, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Evaluating the Alzheimer's Association Training Program for Direct Care Staff
Investigator-Initiated Research Grant—$240,000 over three years

Ohio

Katherine S. Judge, Ph.D.
Benjamin Rose Institute
Cleveland, Ohio
Strength-Based Skills Training for Caregiving Dyads with Dementia
New Investigator Research Grant—$99,997 over two years
Supported through the generosity of Morris Friedell *

Jeffrey Kuret, Ph.D.
Ohio State University Research Foundation
Columbus, Ohio
Triggers and Enhancers of Tau Filament Formation
Investigator-Initiated Research Grant—$240,000 over three years

Bruce T. Lamb, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Gene-Environment Interactions in Alzheimer's Disease Mouse Models
Zenith Fellows Award—$250,000 over two years
Supported through the generosity of the Zenith Fellows

Chien-Liang G. Lin, Ph.D.
Ohio State University Research Foundation
Columbus, Ohio
RNA Oxidation in Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Xiongwei Zhu, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Physiological Regulation of Tau Phosphorylation
New Investigator Research Grant—$100,000 over two years

Oklahoma

H. Anne Pereira, Ph.D.
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
CAP37, A Mediator of Neuronal Microglial Interactions
Investigator-Initiated Research Grant—$240,000 over three years

Oregon

Misha Pavel, Ph.D.
Oregon Health and Science University
Beaverton, Oregon
Tailored Interactive Video Exercise and Cognitive Rehabilitation
Everyday Technologies for Alzheimer Care—$200,000 over three years

Jacob Raber, Ph.D.
Oregon Health and Science University
Portland, Oregon
Neurogenesis and Cognition in Irradiated APOE Mice
Investigator-Initiated Research Grant—$240,000 over three years
Supported through the generosity of the Oregon Research Alliance and the Alzheimer's Association - Oregon Chapter

Pennsylvania

Karen B. Hirschman, Ph.D.
University of Pennsylvania
Philadelphia, Pennsylvania
Redesigning the Hospice Medicare Benefit for Persons With Advanced Dementia
New Investigator Research Grant—$99,998 over two years

Howard D. Wactlar, M.S.
Carnegie Mellon University
Pittsburgh, Pennsylvania
Machine Video and Audio Understanding for Monitoring Dementia Behavior
Everyday Technologies for Alzheimer Care—$199,733 over three years

South Carolina

Yan Zhou, Ph.D.
Medical University of South Carolina
Charleston, South Carolina
Mevalonate Biosynthetic Pathway in APP Processing
New Investigator Research Grant—$100,000 over two years

Tennessee

Charles R. Sanders, Ph.D.
Vanderbilt University Medical Center
Nashville, Tennessee
Familial Alzheimer's Disease Mutations in the Amyloid Precursor Protein
Investigator-Initiated Research Grant—$240,000 over three years

Xuemin Xu, Ph.D.
University of Tennessee
Knoxville, Tennessee
Determine the Role of the Long Beta-Amyloid 46 in Alzheimer's Disease Development
Investigator-Initiated Research Grant—$240,000 over three years

Texas

Juan Botas, Ph.D.
Baylor College of Medicine
Houston, Texas
Screen for Genetic Modifiers in a Drosophila Model of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Kelly Dineley, Ph.D.
University of Texas Medical Branch at Galveston
Galveston, Texas
NF-kB Signaling Axis as a Target in Alzheimer's Disease Therapy
New Investigator Research Grant—$100,000 over two years

Eric Klann, Ph.D.
Baylor College of Medicine
Houston, Texas
Identification of Sources of Oxidative Stress in Alzheimer's Disease Model Mice
Investigator-Initiated Research Grant—$240,000 over three years

Virginia

Barbara M. Freund, Ph.D.
Eastern Virginia Medical School
Norfolk, Virginia
Enhancing Independence: Prescribing Strategies to Promote Continued Driving
Investigator-Initiated Research Grant—$239,967 over three years
Supported through the generosity of Morris Friedell *

Washington

Ian A. D'Souza, Ph.D.
Seattle Institute for Biomedical and Clinical Research
Seattle, Washington
Regulators of Tau mRNA and Protein Expression and Axonal Localization
New Investigator Research Grant—$100,000 over two years

Wisconsin

Regina M. Murphy, Ph.D.
University of Wisconsin at Madison
Madison, Wisconsin
The Two Faces of Transthyretin: TTR's Role in Beta-Amyloid Aggregation
Investigator-Initiated Research Grant—$239,432 over three years

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