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Funded Studies 2005-2013


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Funded Studies: 2006


Canada

A. Claudio Cuello, Ph.D.
McGill University
Montreal, Québec, Canada
Altered NGF Maturation and Degradation in Alzheimer's Disease
Investigator-Initiated Research Grant—$237,916 over three years

France

Jean-Charles Lambert, Ph.D.
INSERM, Institut Pasteur de Lille
Lille, France
Enzymes of the Urea Cycle as Candidate Genes for Alzheimer's Disease?
Investigator-Initiated Research Grant—$239,961 over three years

Germany

Mathias Jucker, Ph.D.
Hertie-Institute for Clinical Brain Research
Tuebingen, Germany
Exogenous Induction of Cerebral Amyloidogenesis
Zenith Fellows Award—$250,000 over two years

Italy

Antonino Cattaneo, Ph.D.
European Brain Research Institute
Rome, Italy
Recombinant Antibodies Against Beta-Amyloid Oligomers: In Vivo Targeting and Delivery
Investigator-Initiated Research Grant—$240,000 over three years

The Netherlands

Monique Breteler, Ph.D.
Erasmus Medical College
Rotterdam, The Netherlands
Metabolic Syndrome, Insulin Metabolism and the Risk of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

United Kingdom

David Craig, M.D.
Belfast City Hospital
Belfast, United Kingdom
Cell Phone Video Streaming in Alzheimer's Disease
Everyday Technologies for Alzheimer's Care—$196,094 over three years

Christopher C.J. Miller, Ph.D.
Institute of Psychiatry
London, United Kingdom
The X11alpha Adaptor Protein, Copper Metabolism and Alzheimer's Disease
Investigator-Initiated Research Grant—$235,919 over three years

UNITED STATES

Arizona

Douglas G. Walker, Ph.D.
Sun Health Research Institute
Sun City, Arizona
CD200 as a Therapeutic Target for Alzheimer's Disease
Investigator-Initiated Research Grant—$239,079 over three years

Arkansas

Gerald A. Dienel, Ph.D.
University of Arkansas for Medical Sciences
Little Rock, Arkansas
Astrocytic Metabolite Trafficking and Brain Imaging in Alzheimer Model Mice
Investigator-Initiated Research Grant—$239,875 over three years

California

Katrin Andreasson, M.D.
Stanford University
Stanford, California
Function of PGE2 Receptors in the Development of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Deborah E. Barnes, Ph.D.
University of California, San Francisco
San Francisco, California
Computer-Based Training in Older Adults With Memory Complaints
Investigator-Initiated Research Grant—$240,000 over three years

Dale E. Bredesen, M.D.
Buck Institute for Age Research
Novato, California
A Role for the Intracytoplasmic Cleavage of APP in Alzheimer's Disease
Investigator-Initiated Research Grant—$239,978 over three years

James E. Hall, Ph.D.
University of California, Irvine
Irvine, California
A Proposed Mechanism for Amyloid Toxicity
Investigator-Initiated Research Grant—$225,934 over three years

Joanna L. Jankowsky, Ph.D.
California Institute of Technology
Pasadena, California
Combination Therapy for the Treatment of Alzheimer's Disease
New Investigator Research Grant—$99,924 over two years

Lee-Way Jin, Ph.D.
University of California, Davis
Sacramento, California
The Use of Novel Amyloid Binding Ligands for Anti-Amyloid Therapies
Investigator-Initiated Research Grant—$240,000 over three years

Rakez Kayed, Ph.D.
University of California, Irvine
Irvine, California
Amyloids as Toxins: Probing Common Structural and Functional Properties
New Investigator Research Grant—$100,000 over two years

Francesca-Fang Liao, Ph.D.
Burnham Institute for Medical Research
La Jolla, California
sAPP and p25/CDK5 in Neurogenesis and Neuronal Death
Investigator-Initiated Research Grant—$240,000 over three years

Bingwei Lu, Ph.D.
Palo Alto Institute for Research & Education, Inc.
Palo Alto, California
Signaling Mechanisms That Link APP and Tau
2007 Investigator-Initiated Research Grant$240,000 over three years

Albert Rizzo, Ph.D.
University of Southern California
Los Angeles, California
Virtual Reality Visuospatial Assessment as a Predictor of Mild Dementia of the Alzheimer's Type
Everyday Technologies for Alzheimer's Care—$199,998 over three years

Richard T. Robertson, Ph.D.
University of California, Irvine
Irvine, California
Neurotrophin-3: Maintenance of Cholinergic Circuitry
Investigator-Initiated Research Grant—$240,000 over three years

Lon S. Schneider, M.D.
University of Southern California
Los Angeles, California
Development of the Cochrane Fully-Coded Trials Register for Dementia
Senator Mark Hatfield Award for Clinical Research—$233,649 over three years

David R. Schubert, Ph.D.
The Salk Institute for Biological Studies
La Jolla, California
A Novel Mouse Model for Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Gregory V. Simpson, Ph.D.
University of California, San Francisco
San Francisco, California
Novel Tools for Assessing Dynamic Brain Networks and Cognition in Dementia
Everyday Technologies for Alzheimer's Care—$194,568 over two years

Connecticut

ichard H. Fortinsky, Ph.D.
University of Connecticut Health Center
Farmington, Connecticut
Information- and Help-Seeking Experiences Among Hispanic Family Caregivers
Investigator-Initiated Research Grant—$239,931 over three years

Delaware

Neal J. Zondlo, Ph.D.
University of Delaware
Newark, Delaware
Conformational Targeting of Tau and Secretase
New Investigator Research Grant—$100,000 over two years

Florida

Chad Dickey, Ph.D.
University of South Florida
Tampa, Florida
Tau Therapeutic Strategies for Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Jada Lewis, Ph.D.
Mayo Clinic Jacksonville
Jacksonville, Florida
Neuronal Death and Functional Recovery in a Conditional Model of Tauopathy
Investigator-Initiated Research Grant—$239,902 over three years

Spiridon Papapetropoulos, Ph.D.
University of Miami
Miami, Florida
Cyanobacterial Toxin (BMAA) in Brain Tissue and Hair of Alzheimer's Disease Patients
New Investigator Research Grant—$60,000 over one year

Illinois

Konstantinos Arfanakis, Ph.D.
Illinois Institute of Technology
Chicago, Illinois
A Diffusion Tensor MRI Technique for Early Diagnosis of Alzheimer's Disease
New Investigator Research Grant—$99,945 over two years

Vincent Cryns, M.D.
Northwestern University
Chicago, Illinois
Role of Caspase Cleavage of Tau in Neurodegeneration
Investigator-Initiated Research Grant—$240,000 over three years

Madelyn A. Iris, Ph.D.
Council for Jewish Elderly
Chicago, Illinois
Beliefs about Alzheimer's Disease, Dementia, and Aging: Cultural and Social Factors
Investigator-Initiated Research Grant—$199,938 over two years

Hong-Duck Kim, Ph.D.
University of Illinois, Chicago
Peoria, Illinois
A-Beta Vaccines Using Recombinant Viruses
New Investigator Research Grant—$100,000 over two years

William L. Klein, Ph.D.
Northwestern University
Evanston, Illinois
Synaptic Targeting by ADDLs as a Basis for Specific Neurodegeneration in Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Susan W. Liebman, Ph.D.
University of Illinois, Chicago
Chicago, Illinois
Modeling Alzheimer's Disease in Yeast
Investigator-Initiated Research Grant—$121,556 over three years

Judith J. McCann, D.N.Sc.
Rush University Medical Center
Chicago, Illinois
Why Don't People With Alzheimer's Disease Use More Community Services?
Investigator-Initiated Research Grant—$239,772 over three years

Stephen C. Meredith, Ph.D.
University of Chicago
Chicago, Illinois
Structure of Mutant Beta-Amyloid Fibrils Examined by Solid-State NMR
Investigator-Initiated Research Grant—$240,000 over three years

Angele Parent, Ph.D.
University of Chicago
Chicago, Illinois
Role of Cell Adhesion Molecules in Presenilin Animal Models
Investigator-Initiated Research Grant—$240,000 over three years

Murali Prakriya, Ph.D.
Northwestern University
Chicago, Illinois
Aberrant Calcium Signaling Mechanisms in Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Sangram S. Sisodia, Ph.D.
University of Chicago
Chicago, Illinois
Purification and Structural Analysis of Presenilin 1-Gamma-Secretase Complex
Investigator-Initiated Research Grant—$239,868 over three years

Robert J. Vassar, Ph.D.
Northwestern University
Chicago, Illinois
The Role of Intraneuronal Abeta in Alzheimer's Disease Pathophysiology
Investigator-Initiated Research Grant—$239,995 over three years

Alice M. Wyrwicz, Ph.D.
Evanston Northwestern Healthcare Research Institute
Evanston, Illinois
Effect of ApoE Isoform on Hippocampal Microstructure and Function
Investigator-Initiated Research Grant—$240,000 over three years

Chunjiang Yu, Ph.D.
University of Illinois, Chicago
Chicago, Illinois
ApoE Isoform Effect on Intraneuronal Abeta Accumulation
New Investigator Research Grant—$100,000 over two years

Indiana

Laura P. Sands, Ph.D.
Purdue University
West Lafayette, Indiana
Evaluating Community-Based Long-Term Care for Medicaid Dementia Patients
Investigator-Initiated Research Grant—$239,961 over three years

Kenneth Mackie, M.D.
Indiana University
Indianapolis, Indiana
Endocannabinoid Control of Neurotransmitter Release in Alzheimer's Disease
Investigator-Initiated Research Grant—$239,548 over three years

Kentucky

Jeff Keller, Ph.D.
University of Kentucky Research Foundation
Lexington, Kentucky
HDAC Inhibitors and Protein Synthesis in Experimental Models of Alzheimer's Disease
Investigator-Initiated Research Grant—$230,910 over three years

Harry LeVine III, Ph.D.
University of Kentucky Research Foundation
Lexington, Kentucky
Chaperone-Mediated Protein Refolding Dysfunction in Alzheimer s Disease
Investigator-Initiated Research Grant—$237,057 over three years

Jun Zhang, Ph.D.
University of Kentucky Research Foundation
Lexington, Kentucky
Diffusion Tensor MRI Analysis for Early Detection of Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Maryland

Nelson Arispe, Ph.D.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Bethesda, Maryland
Blocking the Abeta Ion Channels Protect the Cell
Zenith Fellows Award—$249,852 over two years

Guo Wei, Ph.D.
Johns Hopkins University
Baltimore, Maryland
Role of Prostaglandin Receptor EP2 in Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Massachusetts

Carmela R. Abraham, Ph.D.
Boston University
Boston, Massachusetts
The Significance of APP Dimerization in Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Steven M. Greenberg, Ph.D.
Massachusetts General Hospital
Boston, Massachusetts
PET Imaging of Cerebral Amyloid Angiopathy With Pittsburgh Compound B
Investigator-Initiated Research Grant—$239,983 over three years

Raymond J. Kelleher III, Ph.D.
Massachusetts General Hospital
Boston, Massachusetts
A Knock-In Mouse Model of Presenilin-Linked Frontotemporal Dementia
Investigator-Initiated Research Grant—$240,000 over three years

Daniel A. Kirschner, Ph.D.
Boston College
Chestnut Hill, Massachusetts
Quantitative Assessment of Potential Amyloid Inhibitors
Investigator-Initiated Research Grant—$240,000 over three years

Cynthia A. Lemere, Ph.D.
Brigham and Women's Hospital, Inc.
Boston, Massachusetts
Protective Effects of Chronic L-NBP Treatment in an Alzheimer's Disease Mouse Model
Investigator-Initiated Research Grant—$240,000 over three years

Tod Machover, M.M.
Massachusetts Institute of Technology
Cambridge, Massachusetts
Creative Music Technologies for Alzheimer's Assessment and Treatment
Everyday Technologies for Alzheimer's Care—$199,988 over three years

Maureen K. O'Connor, Psy.D
Boston University
Bedford, Massachusetts
Self Efficacy Enhancement and Caregiver Intervention Effectiveness
New Investigator Research Grant—$99,955 over two years

Reisa Sperling, M.D.
Brigham and Women's Hospital, Inc.
Boston, Massachusetts
Impact of Amyloid Burden on Memory-Related fMRI Activation
Investigator-Initiated Research Grant—$235,129 over three years

Michigan

David W. Eby, Ph.D.
University of Michigan
Ann Arbor, Michigan
Fitness to Drive in Early Stage Dementia: An Instrumented Vehicle Study
Investigator-Initiated Research Grant—$239,811 over three years

Missouri

James E. Galvin, M.D.
Washington University in St. Louis
St. Louis, Missouri
Factors Predicting Physicians' Intention to Evaluate Patients for Dementia
Investigator-Initiated Research Grant—$239,999 over three years

James Lee, Ph.D.
University of Missouri
Columbia, Missouri
Effects of Beta-Amyloid Peptide on Adhesion Mechanics of Cerebral Endothelium
New Investigator Research Grant—$100,000 over two years

Michael R. Nichols, Ph.D.
University of Missouri
St. Louis, Missouri
Amyloid-Beta Fibrils: A Trigger for the Innate Immune Response
New Investigator Research Grant—$100,000 over two years

New Jersey

David J. Libon, Ph.D.
University of Medicine and Dentistry of New Jersey
Stratford, New Jersey
The Effect of Leukoariosis in Alzheimer's Disease
Investigator-Initiated Research Grant—$194,292 over two years

New York

Jose R. Carrion-Baralt, Ph.D.
Mount Sinai School of Medicine
New York, New York
Normative Neuropsychological Data in Nondemented Puerto Rican Nonagenarians
New Investigator Research Grant—$95,700 over two years

Rashid Deane, Ph.D.
University of Rochester
Rochester, New York
Regulation of Amyloid-Beta Brain Efflux by Copper
Investigator-Initiated Research Grant—$199,990 over two years

Matthew P. DeLisa, Ph.D.
Cornell University
Ithaca, New York
Natural Product-Like Compounds That Inhibit Intracellular Abeta Aggregation
New Investigator Research Grant—$100,000 over two years

Karen E. K. Duff, Ph.D.
The Nathan S. Kline Institute for Psychiatric Research
Orangeburg, New York
p25/CDK5 in Alzheimer's Disease Pathogenesis
Zenith Fellows Award—$250,000 over two years

Bing Gong, M.D.
Columbia University Medical Center
New York, New York
Role of Ubiquitin-C-Terminal Hydrolase L1 in Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Khalid Iqbal, Ph.D.
Research Foundation for Mental Hygiene, Inc., at the New York State Institute for Basic Research
New York, New York
Biomarkers of Neurofibrillary Pathology
Investigator-Initiated Research Grant—$240,000 over three years

Jordi Magrane, Ph.D.
Weill Medical College of Cornell University
New York, New York
Synaptic Damage from Intraneuronal Abeta Accumulation
New Investigator Research Grant—$99,990 over two years

Philippe Marambaud, Ph.D.
The Feinstein Institute for Medical Research
Manhasset, New York
Anti-Amyloidogenic Properties of Resveratrol and Its Analogues
New Investigator Research Grant—$99,419 over two years

Lisa Mosconi, Ph.D.
New York University
New York, New York
Dynamic Brain Imaging Predicts Cognitive Decline in Normal Aging
New Investigator Research Grant—$100,000 over two years

Sophie Restituito, Ph.D.
New York University
New York, New York
Synaptic Functions of the Gamma Secretase
New Investigator Research Grant—$99,998 over two years

Nikolaos K. Robakis, Ph.D.
Mount Sinai School of Medicine
New York, New York
Involvement of the PS1/PI3K/GSK-3 Signaling in Neuronal Apoptosis and Abeta
Investigator-Initiated Research Grant—$240,000 over three years

Michal Schnaider-Beeri, Ph.D.
Mount Sinai School of Medicine
New York, New York
Effects of Glycoxidation on Cognition
New Investigator Research Grant—$100,000 over two years

Scott A. Small, M.D.
Columbia University Medical Center
New York, New York
Retromer-Mutant Mice as a Model of Late-Onset Alzheimer's Disease
Investigator-Initiated Research Grant—$236,772 over three years

Christie L. Teigland, Ph.D.
Foundation for Long Term Care, Inc.
Albany, New York
New Quality of Life Measures to Improve Dementia Care in Nursing Homes
Investigator-Initiated Research Grant—$239,644 over three years

Dominique Toran-Allerand, M.D.
Columbia University Medical Center
New York, New York
Estrogen and Neurogenesis in Aging and Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

William Van Nostrand, Ph.D.
The Research Foundation of SUNY
Stony Brook, New York
Inhibition of Beta-Amyloid Fibrillogenesis by Myelin Basic Protein
Investigator-Initiated Research Grant—$219,000 over three years

Thomas Wisniewski, M.D.
New York University
New York, New York
Mucosal Immunization Therapy in Alzheimer's Disease Mice 
Investigator-Initiated Research Grant—$240,000 over three years

North Carolina

Mary L. Piven, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Developing a Measure of Emotional Care in Nursing Homes
New Investigator Research Grant—$99,973 over two years

Ohio

Margaret P. Calkins, Ph.D.
IDEAS Institute
Kirtland, Ohio
Environmental Modifications to Improve Continence in Homes, Assisted Living and Nursing Homes
Investigator-Initiated Research Grant—$237,491 over three years

Karl Herrup, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Alzheimer's Neuropathology Seen Through the Lens of Cell Cycle Processes
Zenith Fellows Award—$250,000 over two years

Gary Landreth, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Mechanisms of Statin-Mediated Regulation of APP Metabolism
Investigator-Initiated Research Grant—$240,000 over three years

Lawrence M. Sayre, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Lipid Oxidation in Alzheimer's Disease: Mechanisms of Toxicity and Potential Intervention
Investigator-Initiated Research Grant—$239,973 over three years

Kathleen A. Smyth, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Using Personal Computers to Extend Impacts of a Caregiving Intervention
Investigator-Initiated Research Grant—$240,000 over three years

Riqiang Yan, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Reticulon Proteins in the Formation of Neuritic Plaques
Investigator-Initiated Research Grant—$240,000 over three years

Oklahoma

J. Neil Henderson, Ph.D.
University of Oklahoma
Oklahoma City, Oklahoma
Dementia Among American Indians: Culture, Caregiving, and Services
Investigator-Initiated Research Grant—$239,995 over three years

Pennsylvania

Paul H. Axelsen, M.D.
University of Pennsylvania
Philadelphia, Pennsylvania
The Structure of Neurotoxic Intermediate Forms of Amyloi- Beta Proteins
Zenith Fellows Award—$250,000 over two years

Peter W. Baas, Ph.D.
Drexel University
Philadelphia, Pennsylvania
Abnormal Microtubule Severing in Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Radosveta Koldamova, Ph.D.
University of Pittsburgh
Pittsburgh, Pennsylvania
LXR Receptors and Alzheimer's Disease
Investigator-Initiated Research Grant—$239,999 over three years

Tennessee

Jonathan L. Haines, Ph.D.
Vanderbilt University Medical Center
Nashville, Tennessee
Identifying the Chromosome 10 Risk Gene for Alzheimer Disease
Investigator-Initiated Research Grant—$239,886 over three years

Texas

Ilya B. Bezprozvanny, Ph.D.
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas
Presenilins and Calcium Signaling: Implications for Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years

Ramon Diaz-Arrastia, Ph.D.
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas
Elevated Homocysteine as a Risk Factor for Progression from MCI to Alzheimer's Disease
Zenith Fellows Award—$250,000 over two years

Roger N. Rosenberg, M.D.
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas
Gene Vaccination for Therapy and Prevention of Alzheimer's Disease
Investigator-Initiated Research Grant—$240,000 over three years
Supported through the generosity of Mr. and Mrs. Alan Losinger

Hui Zheng, Ph.D.
Baylor College of Medicine
Houston, Texas
Regulation of the High-Affinity Choline Transporter by APP
Investigator-Initiated Research Grant—$240,000 over three years

Washington

Suman Jayadev, M.D.
University of Washington
Seattle, Washington
Presenilins and Microglia in Alzheimer's Disease
New Investigator Research Grant—$100,000 over two years

Wisconsin

Craig S. Atwood, Ph.D.
University of Wisconsin, Madison
Madison, Wisconsin
Leuprolide Acetate in the Treatment of Alzheimer's Disease
Zenith Fellows Award—$250,000 over two years

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