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Funded Studies: 2012


AUSTRALIA

Lars M. Ittner, M.D.
The University of Sydney
Sydney, Australia
The Role of Tau in Excitotoxicity in Alzheimer's Disease  
2012 New Investigator Research Grant—$99,400 over two years

CANADA

Jed Meltzer, Ph.D.
Rotman Research Institute of Baycrest
Toronto, Canada
Detection of Early Cortical Pathology Using MEG and Speech Analysis  
2012 New Investigator Research Grant—$97,090 over two years

Dallas P. Seitz, M.D.
Queen's University at Kingston
Kingston, Ontario, Canada
A Volunteer-Led Intervention to Reduce Behavioral Symptoms of Dementia  
2012 New Investigator Research Grant—$100,000 over two years

Kaori Takehara-Nishiuchi, Ph.D.
University of Toronto
Toronto, Ontario, Canada
Physiological Basis of Memory Impairments in Rat Model of Early-Stage Alzheimer's Disease
2012 New Investigator Research Grant—$100,000 over two years

CHILE

Claudio A. Hetz, Ph.D.
Institute of Biomedical Sciences, University of Chile
Santiago, Chile
Protective Role of the Transcription Factor XBP1 in Alzheimer's Disease  
2012 New Investigator Research Grant—$100,000 over two years

CHINA

Gongping Liu, Ph.D.
Huazhong University of Science and Technology
Wuhan, China
Spatial Learning on Neurogenesis and Behavior in Alzheimer's-Like Models  
2012 New Investigator Research Grant—$100,000 over two years

FRANCE

Yuri Zilberter, Ph.D.
Institut de Neuroscience des Systèmes (UMR1106), INSERM
Marseille, France
Energy Substrates as a Tool for Treatment of Hyperexcitability in Alzheimer's Disease
2012 Neuronal Hyperexcitability in Seizures and Alzheimer's Disease Research Grant—$396,969 over three years

GERMANY

Andreas M. Grabrucker, Ph.D.
University Hospital Ulm
Ulm, Germany
Investigating the Physiological Role of Zinc Binding to Beta-Amyloid  
2012 New Investigator Research Grant—$100,000 over two years

ITALY

Cristina Marchetti, Ph.D.
European Brain Research Institute
Rome, Italy
Learning From Epilepsy to Understand Alzheimer's Disease  
2012 New Investigator Research Grant—$100,000 over two years

Giovanni Meli, Ph.D.
European Brain Research Institute
Rome, Italy
Targeting Subcellular Beta-Amyloid Oligomers in Human Alzheimer's Primary Cells  
2012 New Investigator Research Grant—$100,000 over two years

NETHERLANDS

Jeroen J.M. Hoozemans, Ph.D.
VU University Medical Center Amsterdam
Amsterdam, Netherlands
Age-Dependent Toll-Like Receptor Signalling in the Alzheimer's Brain  
2012 New Investigator Research Grant—$99,857 over two years

SPAIN

Francisco J. Gil-Bea, Ph.D.
Foundation for Applied Medical Research
Pamplona, Spain
Pharmacological Manipulation of BDNF as Therapeutic Challenge for Alzheimer's Disease
2012 New Investigator Research Grant—$100,000 over two years

SWEDEN

Susanne Frykman, Ph.D.
Karolinska Institutet
Stockholm, Sweden
Synaptic Production of Beta-Amyloid Peptide and Targeted Inhibition Thereof  
2012 New Investigator Research Grant—$99,000 over two years

UNITED KINGDOM

Chris Nugent, Ph.D.
University of Ulster
Newtownabbey, United Kingdom
TAUT: Technology Adoption and Prediction Tool for Everyday Technologies
2012 Everyday Technologies for Alzheimer's Care—$199,790 over three years

UNITED STATES

Arizona

Boris Decourt, Ph.D.
Banner Sun Health Research Institute
Sun City, Arizona
Preclinical Testing of Lenalidomide as Anti-Amyloid Treatment for Alzheimer's Disease  
2012 New Investigator Research Grant—$100,000 over two years

California

Michael G. Agadjanyan, Ph.D., D.Sc.
Institute for Molecular Medicine
Huntington Beach, California
Immune Mechanisms Involved in Responses to Multiepitope Alzheimer's Disease Vaccine
2012 Investigator-Initiated Research Grant—$239,503 over three years

Mathew M. Blurton-Jones, Ph.D.
University of California, Irvine
Irvine, California
Testing the Therapeutic Efficacy of Neprilysin-Expressing Neural Stem Cells  
2012 New Investigator Research Grant—$100,000 over two years

Owen T. Carmichael, Ph.D.
University of California, Davis
Davis, California
Imaging Biomarkers of Preclinical Cerebrovascular Disease  
2012 New Investigator Research Grant—$100,000 over two years

Kim Green, Ph.D.
University of California, Irvine
Irvine, California
Role of Microglia in Alzheimer's and in Abeta and Tau Immunotherapy  
2012 New Investigator Research Grant—$100,000 over two years

Joshua Grill, Ph.D.
University of California, Los Angeles
Los Angeles, California
Barriers to Enrollment in Preclinical Alzheimer's Disease Clinical Trials  
2012 New Investigator Research Grant—$100,000 over two years

Masashi Kitazawa, Ph.D.
University of California, Merced
Merced, California
Neuroinflammation-Induced Alterations of GLT-1 and Synaptotoxicity in Alzheimer's Disease
2012 New Investigator Research Grant—$100,000 over two years

Gil Rabinovici, M.D.
University of California, San Francisco
San Francisco, California
Imaging and CSF Biomarkers in the Diagnosis of Early-Onset Dementia
2012 Investigator-Initiated Research Grant—$200,000 over three years

David Schubert, Ph.D.
Salk Institute for Biological Studies
La Jolla, California
The Role of the Unfolded Protein Response in Preventing Amyloid Toxicity
2012 Investigator-Initiated Research Grant—$240,000 over three years

Maggie Syme, Ph.D.
San Diego State University Research Foundation
San Diego, California
Examining Sexual Consent Capacity in Cognitively Compromised Older Adults  
2012 New Investigator Research Grant—$99,998 over two years

Vitaly Vasilevko, Ph.D.
University of California, Irvine
Irvine, California
Pyroglutamate-Modified Abeta Species in Alzheimer's Disease: Target for Immunotherapy
2012 New Investigator Research Grant—$100,000 over two years

Colorado

Michael McMurray, Ph.D.
University of Colorado
Denver, Colorado
Mechanisms of Misfolding and Aggregation of Septin Proteins in Alzheimer's
2012 New Investigator Research Grant to Promote Diversity—$99,998 over two years

Delaware

David W. Colby, Ph.D.
University of Delaware
Newark, Delaware
Generation of Diverse Neural Culture Models of Alzheimer's Disease by Cell Reprogramming  
2012 New Investigator Research Grant—$100,000 over two years

Florida

Jose F. Abisambra, Ph.D.
University of South Florida
Tampa, Florida
Mechanisms of Tau and ER Stress for Novel Alzheimer's Disease Therapeutics
2012 New Investigator Research Grant to Promote Diversity—$100,000 over two years

Guojun Bu, Ph.D.
Mayo Clinic Jacksonville
Jacksonville, Florida
LRP1 and HSPG in Cerebrovascular Clearance of ABeta
2012 Investigator-Initiated Research Grant—$240,000 over three years

Daniel C. Lee, Ph.D.
University of South Florida
Tampa, Florida
Impact of Arginase-1 Deficiency on Tau and Amyloid Pathogenesis
2012 Mentored New Investigator Research Grant to Promote Diversity—$149,774 over two years

Georgia

Thomas Kukar, Ph.D.
Emory University
Atlanta, Georgia
The Role of Progranulin in Alzheimer's Disease  
2012 New Investigator Research Grant—$100,000 over two years

Nicholas Seyfried, Ph.D.
Emory University
Atlanta, Georgia
Early Changes in the Brain Proteome and Alzheimer's Disease Risk  
2012 New Investigator Research Grant—$100,000 over two years

Illinois

Daniel Llano, M.D., Ph.D.
University of Illinois, Urbana-Champaign
Urbana, Illinois
Diminished Cortical GABAergic Inhibition in a Mouse Model of Alzheimer's Disease  
2012 New Investigator Research Grant—$100,000 over two years

Kalipada Pahan, Ph.D.
Rush University Medical Center
Chicago, Illinois
Induction of BDNF and NT-3 by Cinnamon Metabolite Sodium Benzoate
2012 Investigator-Initiated Research Grant—$239,910 over three years

Kulandaivelu S. Vetrivel, Ph.D
The University of Chicago
Chicago, Illinois
Proteomic Analysis of Gamma-Secretase Residing in Raft Domains
2012 New Investigator Research Grant—$100,000 over two years

Jennifer Weuve, Sc.D.
Rush University Medical Center
Chicago, Illinois
The Red Cell Distribution Width, a Potential Marker of Dementia Risk
2012 New Investigator Research Grant—$99,831 over two years

Iowa

Gloria Lee, Ph.D.
University of Iowa
Iowa City, Iowa
Fyn in Tau-Induced Neurodegeneration
2012 Investigator-Initiated Research Grant—$239,250 over three years

Kansas

Lan Guo, Ph.D.
University of Kansas Center for Research
Lawrence, Kansas
CypD and Abeta-Impaired Axonal Mitochondrial Motility and Docking  
2012 New Investigator Research Grant—$100,000 over two years

Massachusetts

Rebecca Amariglio, Ph.D.
Brigham and Women's Hospital
Boston, Massachusetts
Subjective Cognitive Complaints: An Early Indicator of Alzheimer's Disease
2012 New Investigator Research Grant—$96,565 over two years

Shaomin Li, M.D., Ph.D
Brigham and Women's Hospital
Boston, Massachusetts
Abeta Increases Glutamatergic Excitation and Induces Epileptiform Activity  
2012 New Investigator Research Grant—$100,000 over two years

Zhongcong Xie, M.D., Ph.D.
Massachusetts General Hospital
Charlestown, Massachusetts
Development of Safer Anesthesia for People with Alzheimer's Disease
2012 Investigator-Initiated Research Grant—$240,000 over three years

Minnesota

Serguei Pakhomov, Ph.D.
Regents of the University of Minnesota—Twin Cities
Minneapolis, Minnesota
Automated Semantic Indices for Early Detection of Cognitive Changes
2012 Development of New Cognitive Functional Instrumentation in Alzheimer's Disease—$400,000 over two years

Jennifer L. Whitwell, Ph.D.
Mayo Clinic
Rochester, Minnesota
Amyloid-Related Imaging Abnormalities (Microbleeds) in Atypical Alzheimer's Disease
2012 New Investigator Research Grant—$100,000 over two years

Missouri

Abhinav Diwan, M.D.
Washington University
St. Louis, Missouri
Enhancing Lysosome Biogenesis to Prevent Amyloid Plaque Pathogenesis  
2012 New Investigator Research Grant—$100,000 over two years

Jungsu Kim, Ph.D.
Washington University in St. Louis
St. Louis, Missouri
Regulation of LDLR as Alzheimer's Disease Therapeutics  
2012 New Investigator Research Grant—$100,000 over two years

New York

Marie Boltz, Ph.D.
New York University
New York, New York
A Family-Nurse Partnership for Care of Hospitalized Persons With Dementia  
2012 New Investigator Research Grant—$99,979 over two years

Dara Dickstein, Ph.D.
Mount Sinai School of Medicine
New York, New York
Assessing the Effect of Oligomeric Abeta on Neuronal and Synaptic Integrity  
2012 New Investigator Research Grant—$99,979 over two years

Silvia Fossati, Ph.D.
New York University School of Medicine
New York, New York
Death Receptors as Mediators of Amyloid-Induced Cerebrovascular Dysfunction  
2012 New Investigator Research Grant—$100,000 over two years

Stephen D. Ginsberg, Ph.D.
Nathan S. Kline Institute for Psychiatric Research
Orangeburg, New York
Effect of Caloric Restriction on Septohippocampal Neurons in Alzheimer's Disease
2012 Investigator-Initiated Research Grant—$240,000 over three years

Bing Gong, M.D., Ph. D.
Mount Sinai School of Medicine
New York, New York
hFbx2/APP, a Novel Transgenic Mouse Model in the Study of BACE1 Degradation
2012 Investigator-Initiated Research Grant—$240,000 over three years

Angela Kamer, Ph.D.
New York University
New York, New York
Infection/Inflammation and Cognitive Decline  
2012 New Investigator Research Grant—$100,000 over two years

Yueming Li, Ph.D.
Sloan-Kettering Institute for Cancer Research
New York, New York
The Mechanisms of Action of Gamma-Secretase Modulators
2012 Investigator-Initiated Research Grant—$240,000 over three years

Mikako Sakurai, Ph.D
Columbia University
New York, New York
Functional Analysis of Neurons Derived From Alzheimer's Patient iPSCs  
2012 New Investigator Research Grant—$100,000 over two years

Helen E. Scharfman, Ph.D.
Nathan S. Kline Institute for Psychiatric Research
Orangeburg, New York
Circuit-Based Strategies in Alzheimer's Disease and Epilepsy
2012 Neuronal Hyperexcitability in Seizures and Alzheimer's Disease Research Grant—$339,956 over three years

Henrieta Scholtzova, M.D., Ph.D.
New York University School of Medicine
New York, New York
Innate Immunity Stimulation as a Novel Therapeutic Approach in Alzheimer's Disease
2012 Investigator-Initiated Research Grant—$240,000 over three years

Andrew Sharp, Ph.D.
Mount Sinai School of Medicine
New York, New York
DNA Methylation Profiling of Alzheimer's Disease Brains
2012 New Investigator Research Grant—$98,670 over two years

Junichi Shioi, Ph.D.
Mount Sinai School of Medicine
New York, New York
Effect of EphB2/CTF2 Peptide on NMDAR Phosphorylation and Signaling
2012 Investigator-Initiated Research Grant—$240,000 over three years

North Carolina

Steve R. Rapp, Ph.D.
Wake Forest University Health Sciences Center
Winston-Salem, North Carolina
Validation of a Simulation-Based Assessment of Cognitive Functioning
2012 Development of New Cognitive Functional Instrumentation in Alzheimer's Disease—$362,821 over three years

Ohio

Gemma Casadesus Smith, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Modulation of Metabolic Processes to Prevent Alzheimer's Disease
2012 Investigator-Initiated Research Grant—$239,996 over three years

Oregon

Lindsay C. Reese, Ph.D.
Oregon Health & Science University
Portland, Oregon
The Role of Amyloid Deposition in Blood-Brain-Barrier Dysfunction in Alzheimer's Disease
2012 U.S.–U.K. Young Investigator Exchange Fellowship—$259,998 over three years

Eric Wan, Ph.D.
Portland State University
Portland, Oregon
A Passive Tag-Free Approach to Localization and Activity Monitoring
2012 Everyday Technologies for Alzheimer's Care—$199,469 over two years

Pennsylvania

Nicholas Fitz, Ph.D.
University of Pittsburgh
Pittsburgh, Pennsylvania
Effect of RXR Agonist on Alzheimer's Phenotype in APP Mice Expressing APOE-e3 and e4
2012 New Investigator Research Grant—$100,000 over two years

Neal Sondheimer, M.D.
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
Alzheimer's Disease and the Destabilization of the Mitochondrial Genome  
2012 New Investigator Research Grant—$99,549 over two years

David A. Wolk, M.D.
University of Pennsylvania
Philadelphia, Pennsylvania
Exploration of Memory Change in Preclinical Alzheimer's Disease
2012 New Investigator Research Grant—$99,840 over two years

South Carolina

Saeid Taheri, Ph.D.
Medical University of South Carolina
Charleston, South Carolina
Monitoring Effect of Hypertension on the BBB in APP Mice Model of Alzheimer's Disease
2012 New Investigator Research Grant—$99,988 over two years

Texas

Muralidhar L. Hegde, Ph.D.
The University of Texas Medical Branch at Galveston
Galveston, Texas
Oxidized Amyloid Proteins Induce Genome Damage in Alzheimer's Disease  
2012 New Investigator Research Grant—$100,000 over two years

Rodrigo Morales, Ph.D.
University of Texas Health Science Center
Houston, Texas
Transmissibility of Amyloid-Beta Deposition by Blood and Different Routes
2012 Mentored New Investigator Research Grant to Promote Diversity—$150,000 over two years

Robia Pautler, Ph.D.
Baylor College of Medicine
Houston, Texas
The Impact of Catalase Overexpression on Alzheimer's Disease Pathology
2012 Investigator-Initiated Research Grant—$200,000, over three years

Qitao Ran, Ph.D.
University of Texas Health Science Center at San Antonio
San Antonio, Texas
Glutaredoxin 2, Mitochondrial Protein Glutathionylation and Alzheimer's Disease
2012 Investigator-Initiated Research Grant—$239,862

Rhonda K. Roby, Ph.D., M.P.H.
University of North Texas Health Science Center
Fort Worth, Texas
A Longitudinal Study of the Changes in mtDNA of People With Alzheimer's Disease
2012 New Investigator Research Grant—$100,000 over two years

Jokubas Ziburkus, Ph.D.
University of Houston
Houston, Texas
Inhibitory Neuron and Circuit Dysfunctions in Alzheimer's Disease Model
2012 New Investigator Research Grant—$100,000 over two years

West Virginia

Miranda N. Reed, Ph.D.
West Virginia University
Morgantown, West Virginia
Effects of Risk Factors on Tau-Mediated Memory Deficits  
2012 New Investigator Research Grant—$97,493 over two years

Wisconsin

Maritza Dowling, Ph.D.
University of Wisconsin-Madison
Madison, Wisconsin
Evaluating the Structural Equivalence of Dementia Screening Tests
2012 New Investigator Research Grant to Promote Diversity—$100,000 over two years

Michael Gitcho, Ph.D.
University of Wisconsin-Madison
Madison, Wisconsin
Age-Dependent Increases of Phosphorylated TDP-43 in APP Mice
2012 New Investigator Research Grant—$100,000 over two years

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