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2005 Grant - Boeve
Treatment of Obstructive Sleep Apnea in Patients With Mild Cognitive Impairment (MCI) or Alzheimer's Disease
Bradley F. Boeve, M.D.
2005 Investigator-Initiated Research Grant
Like Alzheimer's disease, obstructive sleep apnea is a disorder that mostly affects older adults. Caused by temporary obstruction of air passages, apnea can lead to temporary oxygen deprivation, resulting not only in disturbed sleep patterns but also in reduced daytime alertness and perception.
Medical devices that keep the air passages open during sleep have been successfully used to treat sleep apnea. Despite this, there is no data available on the treatment of apnea in people with Alzheimer's disease. In fact, there is little data available on how sleep apnea affects people with Alzheimer's disease or mild cognitive impairment, a disorder that may be a forerunner to Alzheimer's.
Bradley F. Boeve, M.D., and colleagues plan to assess treatment for obstructive sleep apnea in people with Alzheimer's disease or mild cognitive impairment. The researchers predict that those who receive the treatment will experience an improvement in functional ability, daytime wakefulness, mood and overall quality of life. Because sleep apnea in those with Alzheimer's can also affect caregivers or partners, the researchers will also assess potential benefits for those individuals. The findings may help to improve both the diagnosis and treatment of sleep apnea in people with Alzheimer's disease or mild cognitive impairment.