Vote Now
Research Grants - 2005


Alzheimer's Assocation Research only
All of alz.org
  • Go to Alz.org
  • Research Center
  • AAIC
  • ISTAART
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Home
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2005


To view an abstract, select an author from the vertical list on the left side.

2005 Grant - Yan

Role of Mitochondrial Beta-Amyloid in Alzheimer's Disease

Shi Du Yan, M.D.
College of Physicians and Surgeons
Columbia University
New York, New York

2005 Zenith Fellows Award

The beta-amyloid protein fragment aggregates, or clumps together, outside cells. Evidence suggests that some aggregated forms of beta-amyloid may disrupt cell-to-cell communication and contribute to cell death. Other studies have shown, however, that elevated levels of beta-amyloid inside cells apparently occur early in the diseaseóbefore it aggregates outside cellsó
and that these high internal concentrations may cause cellular dysfunction.

Shi Du Yan, M.D., and colleagues are investigating the impact of beta-amyloid on cellular structures called mitochondria, which use oxygen and nutrients to produce energy for a cell. The researchers have speculated that the accumulation of beta-amyloid inside mitochondria alters the function of energy-producing enzymes, the rate of oxygen consumption and the utilization of glucose (sugars).

In this study, the investigators will determine how beta-amyloid enters mitochondria, assess the effect of beta-amyloid on mitochondrial properties and characterize the subsequent impact on cell function. This work may help explain the mechanism of beta-amyloid toxicity and open new lines of investigation for therapies.