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2008 Grants - Battaglia
Boosting Memory in APP/PS1 Mice with Transcranial Magnetic Stimulation
Fortunato Battaglia, Ph.D.
City College of New York and
The Research Foundation of City University of New York
New York, New York
2008 New Investigator Research Grant
Transcranial magnetic stimulation (TMS) is a noninvasive method of stimulating activity in nerve cells of the brain. It is being studied as a potential treatment for certain disorders in the brain, including depression. Fortunato Battaglia, Ph.D., and colleagues are studying TMS as a potential treatment to enhance memory in people with Alzheimer's disease. Using mice as an experimental model, the researchers have found initial evidence that TMS has effects on cognition and memory formation.
Dr. Battaglia and colleagues plan to test whether repetitive use of TMS improves memory in mice that have been genetically altered to express Alzheimer-like pathology. These mice exhibit abnormal function at synapses in the brain, the tiny gaps between the sending and receiving mechanisms of nerves cells that enable the transmission of messages and play an important role in memory.
The researchers plan to test whether TMS restores the normal function and normal biochemistry of brain synapses. They will also test whether TMS can alleviate cognitive abnormalities in mice affected by Alzheimer-like pathology. These studies may provide valuable information about the potential of TMS as a therapy for Alzheimer's disease.