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2011 Grants - Logsdon
Two Interventions for Early Stage Dementia: A Comparative Efficacy Trial
Rebecca G. Logsdon, Ph.D.
University of Washington
2011 Nonpharmacological Strategies to Ameliorate Symptoms of Alzheimer's Disease
Alzheimer's disease (AD) is increasing exponentially, with a projected quadrupling of cases by the mid 21st century. Individuals with Alzheimer's disease are at increased risk for a host of medical and psychiatric conditions, and evidence is accumulating supporting the efficacy and effectiveness of psychosocial interventions for improving their mood, function, health and quality of life. Evidence also exists that such interventions are likely to be most effective when they are implemented during the early stages of dementia. This is when individuals with Alzheimer's and their family members are coping with the initial diagnosis and associated changes in the Alzheimer's patients' abilities and activities.
Recent randomized clinical trials by Rebecca G. Logsdon, Ph.D. and colleagues have developed two promising nonpharmacological interventions to reduce the social, psychological, physical and behavioral impact of dementia. One is a structured 8-session early stage memory loss support group program (ESML) that has been shown to improve quality of life, reduce depressive symptoms, and improve family communication in ESML participants compared to participants in a wait list control condition. The second is a 12-session individual exercise and behavioral intervention (RDAD) that has been shown to increase physical activity, reduce restricted activity days, improve physical function and reduce depression in individuals with mild to moderate dementia.
For this grant, Logsdon and colleagues will conduct a randomized controlled comparative efficacy trial of modified versions of these two evidence-based interventions. The team will analyze social activity participation, family communication, physical activity participation, physical function, overall quality of life and depression. Results will provide the foundation for the development of an NIH proposal to conduct a larger, multisite research trial of these services. If successful, these 4-week programs may be developed into "modules" that can be incorporated into programming for individuals with early stage dementia in a variety of community settings.