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2011 Grants - Van Broeckhoven
Novel Genomic Technologies to Unravel Early-Onset Alzheimer's Etiology
Christine Van Broeckhoven, Ph.D.
Flanders Interuniversity Institute for Biotechnology
2011 Investigator-Initiated Research Grant
Genetic mutations are known to account for some cases of early-onset Alzheimer's disease, which occur before the age of 65 years. In addition, certain genetic variants are known to increase the risk of late-onset Alzheimer's disease. Despite these known links between genes and Alzheimer's disease, many other cases are thought to be caused by mutations or variations in genes that have not been identified.
Christine Van Broeckhoeven, Ph.D., and colleagues have proposed using both new and traditional approaches to identify additional genetic mutations or variations associated with Alzheimer's disease. They will study individuals who are part of a large study of inherited disease in Belgium, as well as additional individuals at the researchers' institution. The researchers will use traditional genetic mapping techniques to identify suspect genes, and novel approaches to map large portions of the entire genetic sequence to identify mutations associated with inherited Alzheimer's disease. These studies may serve as the foundation for further development of treatments to prevent disease in people who inherit a gene that places them at high risk for the disease.