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A Best Place to Work
Alzheimer’s Association Awards Local Research Grants
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The Alzheimer’s Association is proud to be the largest private, non-profit funder of Alzheimer research. We funded 84 out of the 850 research submissions that went through a rigorous peer review process in the past year. Four of those grants went to fund projects right here in the Northern California and Northern Nevada Chapter, including:

Impact of Late-Life Anxiety and Depressive Symptoms on Cognitive Impairment
Sherry Beaudreau, Ph.D., Palo Alto Institute for Research & Education, Inc.
This study aims to investigate the impact of anxiety and depressive symptoms on cognitive decline and progression to cognitive impairment in older adults. Identification of neuropsychiatric markers for cognitive decline would allow for tailored treatment much earlier in the cognitive impairment process targeting anxiety and depressive symptoms – perhaps even before cognitive decline is detected or occurs.

Multi-ethnic Neuropathological Comparison of Alzheimer's Disease: Focus on Control Cases
Lea T. Grinberg, M.D., Ph.D., UCSF
This study looks at brain pathology in more than 500 donated brain specimens. The researchers will determine if donors of different ethnic backgrounds exhibit differences in brain lesions. It will also examine risk factors and genetic characteristics to determine if these characteristics are related to differences in brain pathology. This study could lead to a greater understanding of whether differences in ethnicity, risk factors or genetics may cause different forms of brain pathology.

System for Assessing Speech Feedback Processing in Alzheimer's Disease
John Houde, Ph.D., UCSF
Alzheimer's is associated with a breakdown of frontal cognitive systems related to memory, speech and language. This project provides a system for the automatic assessment of frontal function based on measuring responses to altered auditory feedback during speaking. It allows real-time alterations of auditory feedback during speaking and could be an inexpensive, automated tool for detecting subclinical signs of Alzheimer's disease earlier and measuring the effectiveness of treatments that focus on speech and language in Alzheimer's.

The Role of DJ-1 in Cognitive Impairment
Amy B. Manning-Bog, Ph.D., Stanford
This study examines the role of the DJ-1 gene in Parkinson's disease and dementia. The researchers have shown that lack of a functional DJ-1 gene can lead to cognitive impairment and development of some Alzheimer-like pathologies in the brain. They now plan to perform a detailed analysis of the role of DJ-1 and how its absence leads to a brain condition exhibiting features of both Parkinson's and Alzheimer's.

To read more about studies funded by the Alzheimer’s Association around the nation and world, visit
www.alz.org/research/alzheimers_grants/2009_overview.asp.

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Alzheimer's Association

Our vision: A world without Alzheimer's disease®.
Formed in 1980, the Alzheimer's Association is the world's leading voluntary health organization in Alzheimer's care, support and research.