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2006 Grant - Lemere
Protective Effects of Chronic L-NBP Treatment in an Alzheimer's Disease Mouse Model
Cynthia A. Lemere, Ph.D.
Brigham and Women's Hospital
2006 Investigator Initiated Research Grant
Currently available Alzheimer treatments may alleviate symptoms of the disease, but they do not directly act on disease processes in the brain. A large effort is under way to identify and test disease-modifying drugs that may inhibit Alzheimer pathology.
Cynthia Lemere, Ph.D., proposes to test a novel chemical compound for potential benefits in people with Alzheimer's disease. The chemical, n-butylphthalide (NBP), occurs naturally in the seeds of the Chinese celery plant. A synthetic version of the compound, L-NBP, has been found to reduce inflammation and prevent cell death in genetically altered mice that develop an Alzheimer-like disorder.
Dr. Lemere and colleagues will now test the impact of L-NBP treatment on a broad spectrum of key pathological features in the Alzheimer-like mice. In order to test the compound's effect at various stages of disease progression, they will administer L-NBP to young, middle-aged and older mice. Brain tissue analyses following these treatments may reveal whether the compound can prevent, slow or even reverse the pathology. The researchers will also use behavioral tests to measure cognitive skills in the animals. Findings from this study may provide evidence to plan for future clinical assessments of L-NBP.