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2016 Grants - Mollayeva
Alzheimer's Disease in Men and Women With Central Nervous System Trauma
Tatyana Mollayeva, M.D., Ph.D.
Toronto Rehabilitation Institute-UHN
Toronto, Ontario, Canada
2016 Alzheimer’s Association Research Fellowship (AARF)
What factors impact the relationship between brain trauma and the risk for Alzheimer’s disease?
Central nervous system (CNS) trauma, which can include both spinal cord injury (SCI) and traumatic brain injury (TBI), has been shown to increase the risk for Alzheimer’s disease. Trauma-related dementia risk may be influenced by age, sex or genetic factors, but the underlying mechanisms remain unclear. More research is needed to better understand the complex ways that CNS trauma and the risk for Alzheimer’s disease may be linked.
Tatyana Mollayeva, M.D., Ph.D., and colleagues will explore how CNS trauma may contribute to cognitive decline and Alzheimer’s disease. They will examine medical records of men and women enrolled in the centralized health system of Ontario, Canada and identify individuals who received a diagnosis of CNS trauma (TBI or TBI+SCI). They will then analyze the medical history of these individuals to determine how many of them developed Alzheimer’s disease, what other factors (e.g. age, sex, injury severity) may have contributed to cognitive decline, and the type and effectiveness of any treatment they received. Dr. Mollayeva and colleagues will also share their findings to a wide variety of researchers and policy makers. Such “knowledge translation” will aid in determining practical uses for the study’s results.
The results of this work could shed new light on the factors that may impact the relationship between CNS trauma and Alzheimer’s disease. Importantly, this work could inform the development of therapeutic strategies for individuals with CNS trauma that may reduce the risk of cognitive decline.