On-Demand Webinars for Dementia and Alzheimer’s Researchers

Design and Data Analytics PIA: Bayesian Multi-Timescale Modeling for Disentangling Cognitive Decline and Learning Effects in Repeated Mobile Cognitive Assessments

Recorded on Feb. 22, 2021
In the preclinical phase of Alzheimer’s disease and related dementias, early detection of subtle cognitive decline over time is crucial for facilitating the development of interventions. This endeavor, however, is complicated by the fact that multiple, multi-timescale factors influence changes in cognitive performance measures over time, and careful statistical modeling is required. With the double exponential learning model, we can account for learning effects and stochastic fluctuations in longitudinal studies with high-frequency assessments (i.e., measurement burst studies).

This webinar will demonstrate how a Bayesian multilevel implementation of the double exponential model allows for the inclusion of person-level predictors on learning model parameters and draw intuitive inferences on cognitive change with Bayesian posterior probabilities. Zita Oravecz will use mobile cognitive task performance data to show how individual differences in peak performance and change therein can be related to predictors such as age and MCI status.

Speaker:
Zita Oravecz

Nutrition, Metabolism and Dementia PIA: Creatine Treatment — Promising Approach or Dead End

Recorded on Feb. 16, 2021
Creatine, a dietary supplement, has been tested with increasing interest the last 10 years in both animal models and clinical trials. Studies have shown it provides improvements in muscle strength. Some investigators have also proposed it may supply cognitive benefit in those at risk for dementia and help with mental fatigue, sleep deprivation, traumatic brain injury (TBI) and working memory. Moreover, clinical trials have tested creatine in Huntington's disease (HD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), to name a few. Overall, past results in HD, PD, and ALS have been mixed and many important questions remain.

Given this more research is needed to evaluate creatine's effects specifically on cognition, males vs. females, and if it can lower the risk for MCI in dementia. Interestingly, recent clinical trial data in diabetes patients and data from our transgenic Alzheimer's disease (AD) models suggest creatine improves mitochondrial function, learning, memory and reverses pathology, but in a sex-specific manner.

Speaker:
Benedict C. Albensi

Down Syndrome and Alzheimer’s Disease PIA: Neuroinflammation in Down Syndrome — Role in Alzheimer’s Disease

Recorded on Feb. 10, 2021
This webinar will discuss current research findings on cerebral cytokine expression and microglial phenotypes across the Alzheimer's continuum in individuals with Down syndrome.

Speakers:
Lisi Flores Aguilar and Alessandra Martin

ISTAART Journal Club Meet the Author

Recorded on Feb. 4, 2021
João Pedro Ferrari Souza will lead a conversation with Renaud La Joie and Gil Rabinovici about the paper, Prospective Longitudinal Atrophy in Alzheimer’s Disease Correlates with the Intensity and Topography of Baseline Tau-PET, published in Science Translational Medicine. Hosted by the Neuroimaging PIA.

Maura Malpetti will lead a conversation with Leonardo Iaccarino and Gil Rabinovici about the paper, Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults with Cognitive Impairment, published in JAMA.

Atypical Alzheimer's Disease PIA: Year in Review

Recorded on Jan. 29, 2021
Keir Yong, Alzheimer's Society Fellow, Dementia Research Centre, University College London, will consider 2020 advances in our understanding of atypical Alzheimer’s disease. Key themes will be discussed regarding canonical atypical clinical phenotypes of AD and atypicality based on neuropathology, neuroimaging and molecular biomarker studies. Predictions for 2021 will be made regarding atypical AD research and wider implications regarding phenotypic heterogeneity across the AD spectrum. Moderated by Rik Ossenkoppele and Baayla Boon.

Panelist:
Keir Yong

Chicken, Egg or Both: Progress in Understanding the Association Between Sleep and Circadian Rhythm Disruption and Alzheimer's Disease in 2020

Recorded on Jan. 27, 2021
This webinar will highlight epidemiological and mechanistic studies from the past year linking sleep disruption to Alzheimer's Disease and shedding light on the potentially bidirectional nature of these links. Moderated by Claire Andre and Kristine Wilckens.

Panelist:
Andrew Lim

Perioperative, Cognition and Delirium PIA: Year in Review

Recorded on Jan. 26, 2021
This PIA is founded in the concept that anesthesia and surgery represent a physiological stress that, in a vulnerable brain, may produce delirium and accelerated cognitive decline. COVID-19 might be doing the same. In three brief expert presentations, this webinar will review remote cognitive testing paradigms and existing data linking COVID-19 and altered cognitive states. Moderated by Roderic Eckenhoff and Katie J. Schenning.

Panelists:
Phillip Vlisides, Lis Evered and Catherine Price

From PIs to Participants: Moving Toward Sustainable Representation in Clinical Trials in ADRD

Recorded on Jan. 26, 2021
Hosted by the Clinical Trials Advancement PIA and Methods & Diversity and Disparities PIA, this webinar will address both long-term and short-term solutions to disparities and diversity in the context of ADRD clinical trials. Moderated by Erin Abner and Ganesh Babulal.

Panelists:
Neelum Aggarwal, Joshua Grill and Jonathan Jackson

The Eye as a Biomarker for AD PIA: Year in Review

Recorded on Jan. 25, 2021
This webinar will outline and summarize 2020's most impactful findings in retinal biomarker development in AD, discuss up-and-coming developments for 2021, and the PIA goals to chart a path forward towards retinal biomarker validation in AD. Following these presentations, there will be a group discussion led by the PIA Executive Committee. Moderated by Victoria Pelak and Robert Rissman.

Panelists:
Jessica Alber and Jurre den Haan

Neuromodulatory Subcortical Systems PIA: Updates in Orexinergic, Cholinergic and Noradrenergic Systems in AD and Related Conditions

Recorded on Jan. 25, 2021
Neurotransmitters synthesized in subcortical nuclei, including norepinephrine, serotonin, acetylcholine and orexin regulate most brain functions. These neuromodulatory subcortical systems become dysfunctional already in the first stages of Alzheimer’s disease. Yet, we still know little about the NSS in AD and AD-related disorders. Come to learn, discuss and contribute to this webinar that brings the latest developments on the NSS in AD. Moderated by Martin Dahl, Alexander Ehrenberg and Alexandra Weigand.

Panelists:
Daniel Ferreira Padilla, Lotta Granholm-Bentley and Claudio Liguori

Diversity and Disparities PIA: Year in Review

Recorded on Jan. 21, 2021
Ganesh Babulal discusses the PIA's 2020 accomplishments and the coming year’s agenda. Miguel Arce Rentería presents on the Bilingualism, Literacy and Language (BLL) SIG’s mission, activities and future goals. Jason Flatt discusses the Lesbian, Gay, Bisexual, Trans, Queer/Questioning (LGBTQ) SIG’s activities, including efforts to set forth best practices in data collection of sexual orientation and gender identity and research priorities. Michelle Mielke and Neelum Aggarwal outline the overall goals and efforts of the Sex and Gender SIG, including the discussion of gender as a social construct and of sex and gender from a diversity and disparities perspective.

Design and Data Analytics PIA: Cascading Epigenomic Analysis for GWAS

Recorded on Jan. 20, 2021
This event will present a new multi-omic integration method, CEWAS, that models the cascading effects of SNPs from epigenome to transcriptome and eventually to the phenome for identifying disease genes from GWAS. We show on sixteen brain-related GWAS that CEWAS provides a higher gene detection rate than related methods, and finds less explored disease relevant genes and gene sets. Moderated by Ana Capuano.

Panelist:
Bernard Ng

Technology and Dementia PIA: Year in Review

Recorded on Jan. 20, 2021
This webinar will reflect on key technology and dementia studies and their findings from 2020. The review will consider what may be expected in 2021 in light of a number of technological trends. Moderated by Arlene Astell and Michael Wong.

Panelists:
Andrew Sixsmith, Nicole Bouranis and Ian Cleland

CTAM PIA: 2020, The Impact on Clinical Trials in Dementia and The Path Forward

Recorded on Jan. 14, 2021
This program provides international perspectives on the ways the COVID-19 pandemic has changed clinical trials in dementia and considers the ways forward in the field for trials in 2021 and beyond.

Panelists:
Jort Vijverberg, Ricardo Allegri, Serge Gauthier and Keir Yong

Electrophysiology PIA: Neurophysiological Signals as Translational Biomarkers for Dementia

Recorded on Jan. 14, 2021
The webinar will overview various in vivo neurophysiological measurements in transgenic rodent models of Alzheimer’s disease and fronto-temporal dementia. These studies aim to reveal pathomechanisms involved in human neurodegenerative diseases, provide disease-relevant in vivo efficacy assays for development of novel treatments, and identify potential translational biomarkers for proof-of-mechanism trials. Moderated by Xianghong Arakaki and Francesca Farina.

Panelist:
Mihaly Hajos

Cognition PIA: Cognitive Screening and Testing in a Biomarker Era

Recorded on Jan. 13, 2021
If blood-based biomarker tests are available and new therapies for Alzheimer’s disease are approved, how would we apply cognitive testing to identify who to treat and assess whether treatment is benefiting cognition? Do we need new cognitive tests and methods for screening and monitoring? Our panel of experts from the ISTAART Cognition PIA will discuss these questions.

Tips, Tricks and Insights for How to Review Research Grants

Recorded on Jan. 13, 2021
This webinar will provide an overview of the Alzheimer's Association grant application peer-review process and highlight some of the specific review criteria and important considerations for several of our regularly offered programs. We will be joined by Drs. Cynthia Lemere (BWH), Ezequiel Surace (FLENI), Maria Llorens Martin (CIBERNED), and David Soleimani-Meigooni (UCSF) who will share their experiences to help guide you through this process, provide insights on getting started as a grant peer-reviewer, discuss basic principles of the review process, and share their experiences as both reviewers and as applicants.

Biofluid Based Biomarkers PIA: Year in Review

Recorded on Jan. 11, 2021
The webinar will discuss key findings in the fluid biomarker research space during 2020. Moderated by Henrik Zetterberg and Charlotte Teunissen.

Panelists:
Members of the BBB PIA Executive Committee

ISTAART Journal Club Meet the Author

Recorded on Jan. 7, 2021
Nadia Dehghani will lead a conversation with Nabil F. Darwich, Edward B. Lee and Jessica Phan about the paper, Autosomal Dominant VCP Hypomorph Mutation Impairs Disaggregation of PHF-tau, published in Science.

Ashley Bolte will lead a conversation with David Gate about the paper, Clonally Expanded CD8 T Cells Patrol the Cerebrospinal Fluid in Alzheimer's Disease, published in Nature.

Guide to AAIC 2021: Abstracts

Recorded on Jan. 5, 2021
Join us for a free webinar featuring a step-by-step guide to successful AAIC 2021 abstract submissions; an overview of logistics; and expert insight from Wiesje van der Flier, theme lead for Biomarkers, AAIC 2021 Scientific Program Committee.

What Can you Gain from GAAIN: Overview and Case Specific Applications

Recorded on Dec. 17, 2020
How can you gain from GAAIN? Hear about the latest updates on the Global Alzheimer’s Association Interactive Network (GAAIN), how GAAIN played a critical role in advancing research and how GAAIN helped answer specific research questions. Join this discussion to see how you can use GAAIN can to meet your research needs, including discovering trends in existing Alzheimer’s disease and dementia data.

Speakers:
Arthur Toga, Swati Rane and Feng Cheng

Brain Ageing and Dementia in LMICs 2020 — Day 2

Recorded on Dec. 10, 2020
This virtual conference will provide a forum to discuss risk factors and increasing burden of vascular and neurodegenerative diseases (including HIV dementias) in the context of incidence and prevention in cross-cultural populations in low- and middle-income countries compared to Europe, North America and Japan.

Speakers:
Mohamed Salama, Victor Valcour, Suvarna Alladi, Christopher Chen, Mathew Varghese, Ennapadam Krishnamoorthy, Raul Arizaga, Francisco Lopera, Lea Grinberg, Faheem Arshad, Xu Xin and Ceres Ferretti

Brain Ageing and Dementia in LMICs 2020 — Day 1

Recorded on Dec. 9, 2020
This virtual conference will provide a forum to discuss risk factors and increasing burden of vascular and neurodegenerative diseases (including HIV dementias) in the context of incidence and prevention in cross-cultural populations in low- and middle-income countries compared to Europe, North America and Japan.

Speakers:
David Ndetei, Wendy Weidner, Vincent Mok, Seshadri Seshadri, Albertino Damasceno, Maelenn Guerchet, Stella-Maria Paddick, Katie Roe, Olakunle Adewale and Kirsty Bobrow

Guide to AAIC 2021: Featured Research Sessions — Presented by ISTAART

Recorded on Dec. 8, 2020
Join us for an overview of logistics, a step-by-step guide to successful submissions and expert insight from co-chair of the Scientific Program Committee, Delphine Boche.

NMD PIA: APOE4, Diet and the Brain

Recorded on Nov. 17, 2020
APOE4 induces systemic changes to glucose and lipid metabolism throughout the lifespan that affect brain functions. Understanding these changes is key to designing dietary interventions for the prevention of cognitive decline in older APOE4 carriers. Hosted by the Nutrition, Metabolism and Dementia PIA. Moderated by Cécilia Samieri.

Presenter:
Hussein Yassine

ISTAART Journal Club Meet the Author (Portuguese)

Recorded on Nov. 14, 2020
Tamires Alves will lead a conversation with Marcia M. P. C. Novelli and Laura N. Gitlin about the paper, Effects of the Tailored Activity Program in Brazil (TAP-BR) for Persons with Dementia, published in Alzheimer Disease and Associated Disorders.

Speakers:
Tamires Alves Sarno, Marcia M. P. C. Novelli, Laura N. Gitlin, Naiara Demntiz, Mariana Luciano de Almeida and Wagner Brum

ISTAART Journal Club Meet the Author

Recorded on Nov. 10, 2020
Originally presented at AAIC Neuroscience Next. Caitlin Corona-Long will lead a conversation with Valentina Perose about the paper, Hippocampal Vascular Reserve Associated with Cognitive Performance and Hippocampal Volume, published in Brain.

ISTAART Journal Club Meet the Author

Recorded on Nov. 9, 2020
Originally presented at AAIC Neuroscience Next. Mélise Edwards will lead a conversation with Danlei Bi about the paper, GABAergic Dysfunction in Excitatory and Inhibitory (E/I) Imbalance Drives the Pathogenesis of Alzheimer's Disease, published in Alzheimer’s & Dementia.

The Forgotten Utility of Case Studies: Examining Non-Pharmacologic Interventions in Individuals with ADRD (Part 1)

Recorded on Oct. 27, 2020
While the move toward evaluating treatment effects with ever larger sample sizes comes with many benefits, those with less common types of Alzheimer’s disease and related dementias (ADRD) often fail to meet inclusion criteria and lack the “numbers” to justify a full scale trial. Thus, knowledge about the optimal treatment approaches lag because of this smaller “market share”. This program will embrace the robust history of intervening for, and learning from, individual cases and case series. Moderated by Sietske A.M. Sikkes.

Presenter:
Benjamin M. Hampstead

Ask the Editors — A&D, TRCI and DADM

Recorded on Oct. 21, 2020
Join us for a session to ask the editors of Alzheimer's & Dementia: Journal of the Alzheimer's Association, Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) and Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM). Topics in the webinar include areas of priority for the journals, considerations for those submitting manuscripts, tips for reviews and more.

Speakers:
Peter J. Snyder, Kathleen M. Hayden, Zaven S. Khachaturian and Ara S. Khachaturian

Multidomain Interventions in Dementia Prevention: Recent Successes and Disappointments

Recorded on Oct. 20, 2020
Three recent big clinical trials (FINGER, PREDIVA, MAPT) included nutrition as part of the multidomain intervention. Results were mixed. This presentation will include aspects of the trial design and findings, as well as some attempts to explain a few of the potential reasons of discrepant results. Moderated by Hussein Yassine.

Presenter:
Nikolaos Scarmeas

ISTAART Journal Club Meet the Author

Recorded on Oct. 14, 2020
Naiara Demntiz will lead a conversation with Gill Livingston and Naaheed Mukadam about the paper, Dementia Prevention, Intervention and Care: 2020 Report of the Lancet Commission, published in Lancet 2020.

Mariana Luciano de Almeida will lead a conversation with Anna Marseglia and Weili Xu about the paper, Can Active Life Mitigate the Impact of Diabetes on Dementia and Brain Aging?, published in Alzheimer's & Dementia.

ADAD, EOAD and DSAD: Natural History and Biomarkers

Recorded on Oct. 1, 2020
This webinar will provide an update on our latest understanding of the natural history of Alzheimer's in autosomal dominant, early onset (non-autosomal dominant) and Down syndrome/Alzheimer's populations — similarities and differences in cognition, function and biomarkers (imaging and fluid measures). Moderated by Michael Rafii.

Presenters:
Liana Apostolova and Juan Fortea

ISTAART Journal Club Meet the Author

Recorded on Sept. 30, 2020
Wagner Brum will lead a conversation with Thomas Karikari, Tharick Pascoal and Kaj Blennow about the paper, Blood Phosphorylated Tau 181 as a Biomarker for Alzheimer's Disease: A Diagnostic Performance and Prediction Modelling Study Using Data from Four Prospective Cohorts, published in Lancet Neurology 2020.

Breno Barbosa will lead a conversation with Sebastian Palmqvist about the paper, Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs. Other Neurodegenerative Disorders, published in JAMA 2020.

LAC-CD: Advances in Latin American Research

Recorded on Sept. 23, 2020
The Latin America and Caribbean Consortium on Dementia discusses the latest research updates.

Presenters:
Jorge Llibre Guerra, Mario Parra, Walt Dawson, Nilton Custodio, Laís Fajersztajn and Agustin Ibanez

Research Update: Imaging the Vascular Contribution to Cognitive Impairment

Recorded on Sept. 17, 2020
Part of the Neuroimaging PIA educational series, this webinar presents the scope and latest imaging and methodological advances to understand the role of vascular damage in Alzheimer’s disease and related dementias.

Speakers:
Sandra Black, Carole Sudre and Prashanthi Vemuri

LAC-CD: Advances in Latin American Research

Recorded on Sept. 9, 2020
Updates from the Latin America and Caribbean Consortium on Dementia (LAC-CD) on phenotyping dementias and biomarkers.

Presenters:
Agustin Ibanez, Stefanie Piña Escudero, M.D., Maira Okada, Adolfo Garcia, Christian Gonzalez, Mario Parra, Andres Damian and Claudia Durán

Health Equity, ALZ and Me: Part I

Recorded on July 8, 2020
Race. Socioeconomic position. Inequalities. Disparities. Health equity. How do we define these terms and how do they impact our work in communities? Join us for the first of a three-part webinar series. This presentation for Alzheimer's Association Staff will define health equity and how disproportionate outcomes in Alzheimer's and other dementia affects our communities.

Speaker:
Camara Jones, M.D., M.P.H., Ph.D.

ISTAART Journal Club Meet the Author

Recorded on July 8, 2020
Yuliya Yoskobiynyk will lead a conversation with Yingyue Zhou and Marco Colonna about the paper Human and Mouse Single-Nucleus Transcriptomics Reveal TREM2-Dependent and TREM2-Independent Cellular Responses in Alzheimer's Disease, published in Nature Medicine.

James Quinn will lead a conversation with Erik Johnson and Nicholas Seyfried about the paper Large-Scale Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated With Microglia and Astrocyte Activation, published in Nature Medicine.

COVID-19 Pandemic: Considerations for Reopening Wet Labs

Recorded on July 7, 2020
Join eminent researchers and emerging leaders from around the globe, along with representatives of the Alzheimer's Association and U.S. National Institute on Aging, for a conversation about challenges and opportunities related to reopening wet labs and restarting bench science in the context of the current global pandemic.

Panelists:
Ph.D.s Maria Carrillo, Eliezer Masliah, Malú Gámez Tansey, Bruce Lamb, Donna Wilcock, Robert Rissman, Eleanor Drummond, Jennifer Yokoyama and Selina Wray

ISTAART Journal Club Meet the Author

Recorded on July 1, 2020
Oz Ismail will lead a conversation with Axel Montagne and Berislav V. Zlokovic about the paper APOE4 Leads to Blood-Brain Barrier Dysfunction Predicting Cognitive Decline, published in Nature.

Lindsay Welikovitch will lead a conversation with Lay Kodama about the paper Microglial microRNAs Mediate Sex-Specific Responses to Tau Pathology, published in Nature Neuroscience.

ISTAART Journal Club Meet the Author

Recorded on June 24, 2020
Alexander Ehrenberg will lead a conversation with Val Lowe and Melissa Murray about the paper Tau-positron Emission Tomography Correlates With Neuropathology Findings, published in Alzheimer's & Dementia.

Karen Dorsman will lead a conversation with Miguel Arce Renterίa and Jennifer J. Manly about the paper Illiteracy, Dementia Risk, and Cognitive Trajectories Among Older Adults With Low Education, published in Neurology.

COVID-19 and Guidance for Clinical Studies

Recorded on June 23, 2020
This webinar focuses on guidance on scientific/medical practices for clinical studies related to Alzheimer's and related dementias, including the challenges, opportunities and adjustments regarding research activities and their sites.

Speakers:
Ph.D.s Greg Jicha, José Luis Molinuevo and Vijayalakshmi Ravindranath

International Alzheimer's Symposium Spanish Webinar

Recorded on June 20, 2020
The Alzheimer's Association — in collaboration with UCSF, Global Brain Health Institute and Well Connected Español — invites you to the first International Alzheimer's Symposium for families facing this disease and public in general via Zoom and Facebook. Neurologists and Geriatric specialists will present virtually on issues about Alzheimer's disease including latest advances in research, clinical studies and how to care for the caregiver.

COVID-19 in Down Syndrome and Alzheimer's Research

Recorded on June 9, 2020
ISTAART members only. This webinar will focus on the impact of COVID-19 on clinical trials involving people living with Down Syndrome and Alzheimer’s Disease. Moderated by Katherine Koenig, Ph.D.

Presenters:
Ph.D.s Joaquin Espinosa and Florencia Iulita

How to Use GAAIN for Your Research: Data Discovery and Interrogator

Recorded on June 8, 2020
Data discovery and interrogation from multiple studies need a platform to collect information. The Global Alzheimer's Association Interactive Network (GAAIN) team and two Alzheimer's Association fellow awardees discuss how they apply data discovery and interrogation to their work.

Presenters:
Ph.D.s Arthur Toga, Christopher Kaufmann and Duygu Tosun-Turgut

Design, Deliver and Promote Engaging Virtual Presentations: Poster and Oral at AAIC 2020

Recorded on June 4, 2020
Learn tips on designing, promoting and delivering engaging virtual presentations — both for virtual posters and oral sessions at AAIC 2020.

Design and Data Analytics (DaDA)

Recorded on June 3, 2020
ISTAART members only. The DaDA PIA will host its next hour-long webinar, within- and between-person change and variation in longitudinal designs. Reference the ISTAART Member Center, email communications and calendar invitations for call-in details. Moderated by Philippe Rast, Ph.D.

Impact of COVID-19 Pandemic on Research, Career Considerations and Future Planning

Recorded on May 12, 2020
This webinar is focused on the workforce – what are considerations and activities to support the research workforce at every career level. Moderated by Malú Tansey, Ph.D.

Panelists:
Ph.D.s Nicola Lautenschlager, Melissa Murray, Rachel Whitmer and Henrik Zetterberg

Impact of COVID-19 on Clinical and Social Behavioral Research (Intervention and Observation)

Recorded on May 5, 2020
This virtual discussion addresses the opportunities and challenges affecting how researchers, departments and collaborators are connecting during social distancing and stay at home orders, and share their Sharing plans for re-opening and re-initiating work. Moderated by Ph.D.s David Knopman and Mary Sano.

Panelists:
Ph.D.s Laura Baker, CJ Barnum, José Luis Molinuevo, Kendra Ray and Reisa Sperling