Preconference: Alzheimer's Imaging Consortium

Saturday, July 13, 2019
Preconference: 8 a.m. – 5:45 p.m.
Los Angeles Convention Center, Room 403 AB
Reception: 6 p.m.
Intercontinental Los Angeles Downtown Hotel, Wilshire Grand 2-3

Overview

The Alzheimer's Imaging Consortium (AIC), a preconference to the Alzheimer's Association International Conference® (AAIC®), will focus on the clinical application and methodological development of neuroimaging (MRI, PET, SPECT, CT and others) to Alzheimer's disease, other dementias and normal brain aging. The program consists of invited speakers, as well as oral and poster presentations from submitted abstracts.

This preconference was organized by the ISTAART Neuroimaging PIA.

Organizing Committee


Agenda
  • Time
  • Session

8 - 8:15 a.m.

Opening Remarks
Bradford C. Dickerson, Harvard Medical School; Massachusetts General Hospital, United States


8:15 - 8:45 a.m.

IC-01: Plenary Session: What Have We Learned?
Laura Wisse, Ph.D., University of Pennsylvania, Philadelphia, United States


8:45 - 10 a.m.

IC-02: Longitudinal Imaging

Grey Matter Connectivity Trajectories Across the Alzheimer’s Disease Continuum and Associations With Cognitive Decline
Ellen Dicks, Wiesje van der Flier, Frederik Barkhof, Philip Scheltens, Betty Tijms

Longitudinal Evaluation of Tau Propagation Using [18f]MK-6240
Tharick Pascoal, Mira Chamoun, Min Su Kang, Andrea Benedet, Joseph Therriault, Melissa Savard, Sulantha Mathotaarachchi, Cecile Tissot, Muhammad Qureshi, Firoza Lussier, Marlee Parson, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto

Mild Cognitive Impairment Progressing to Dementia With Lewy Bodies: Regional Atrophy Rates and Relationship to AV-1451 Uptake
Zuzana Nedelska, Brad Boeve, Tanis Ferman, Matthew Senjem, Scott Przybelski, Timothy Lesnick, David Knopman, Jonathan Graff-Radford, David Jones, Rodolfo Savica, Daniel Drubach, Julie Fields, Neill Graff-Radford, Val Lowe, Clifford Jack, Ronald Petersen, Kejal Kantarci

Novel Measures of Longitudinal Change in Medial Temporal Lobe Subregions Discriminate Preclinical Alzheimer’s Disease Patients From Amyloid-β Negative Controls
Long Xie, Laura Wisse, Sandhitsu Das, Ranjit Ittyerah, de Flores Robin, Paul Yushkevich, David Wolk

Gender Differences in the Association Between Longitudinal Brain Changes and Baseline Levels of CSF Alzheimer's Disease and Glial Biomarkers in Healthy Elders
Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Raquel Sanchez-Valle, Lorena Rami, Beatriz Bosch-Capdevila, Anna Antonell, Juan Domingo Gispert, José Luis Molinuevo


10 - 10:15 a.m.

Break


10:15 - 10:45 a.m.

DB-01: Data Blitz Presentations

Temporal Trajectories of In Vivo Tau and Amyloid-β Accumulation in Alzheimer’s Disease
Hanna Cho, Min seok Baek, Jae Yong Choi, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyoo

Vascular Risk Factors and Multimodal Neuroimaging Biomarkers: Preliminary Analyses From the Multi-Ethnic Study of Atherosclerosis (MESA)
Samuel Lockhart, Suzanne Craft, Bonnie Sachs, Stephen Rapp, Youngkyoo Jung, Christopher Whitlow, Kiran Kumar Solingapuram Sai, Kathleen Hayden, Gregory Burke, Timothy Hughes

Global Cortical [F18]Flortaucipir Association With the Top 20 Alzheimer’s Disease Risk Genes
Eddie Stage, Shannon Risacher, Naira Goukasian, Kwangsik Nho, Andrew Saykin, Liana Apostolova

Cerebral Amyloid Angiopathy Is More Severe in Autosomal Dominant AD Cases With Cerebral Microhemorrhages: Results From the DIAN Study
Nelly Joseph-Mathurin, Richard Perrin, Nigel Cairns, Erin Franklin, Chengjie Xiong, Gregory Preboske, Clifford Jack, John Morris, Randall Bateman, Tammie Benzinger

Longitudinal Associations Between Plasma Nfl and Voxel-Based Morphometry in Alzheimer’s Disease
Andrea Benedet, Antoine Leuzy, Tharick Pascoal, Nicholas Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto


10:45 - 11:15 a.m.

IC-03: Plenary Session: Preclinical Cognitive Decline Is Related to Tau and Amyloid Imaging Profiles in a Risk-Enriched Cohort

Sterling Johnson, Ph.D.
Wisconsin Alzheimer Disease Research Center; University of Wisconsin School of Medicine and Public Health, United States


11:15 a.m. - 12:30 p.m.

IC-04: Imaging Non-AD Pathologies

The Search for Pathologically Valid Imaging Biomarkers - AD Pathology Comes Not Alone
Stefan Teipel, Michel Grothe

Ante-Mortem Volume Loss Mirrors TDP43 Staging in Non-FTLD Older Adults
Alexandre Bejanin, Melissa Murray, Peter Martin, Hugo Botha, Nirubol Tosakulwong, Christopher Schwarz, Matthew Senjem, Gaelle Chetelat, Clifford Jack, Bradley Boeve, David Knopman, Ronald Petersen, Caterina Giannini, Joseph Parisi, Dennis Dickson, Jennifer Whitwell, Keith Josephs

Utility of MRI in Detection of Atrophy in Hippocampal Sclerosis of Aging
Davis Woodworth, Hannah Nguyen, Zainab Khan, S. Ahmad Sajjadi

Iron, Neurodegeneration, Tau, and Amyloid in Patients With Alzheimer’s Disease
Suzanne Baker, Renaud La Joie, Chunlei Liu, Yann Cobigo, Viktoriya Bourakova, Theresa Harrison, Gil Rabinovici, William Jagust

Cross-Sectional and Longitudinal Medial Temporal Lobe Subregional Atrophy in Suspected Non-Alzheimer’s Pathophysiology
Laura Wisse, Long Xie, Sandhitsu Das, Robin de Flores, Paul Yushkevich, David Wolk


12:30 - 2 p.m.

Poster Viewing and Lunch (included)


2 - 3 p.m.

IC-05: Debate: MRI Versus PET: Which Imaging Modality Provides the Best Biomarker and for Which Purpose?

Michael Weiner, MD
University of California, San Francisco, United States

Mark Mintun, M.D.
Avid Radiopharmaceuticals, United States


3 - 4:15 p.m.

IC-06: Imaging in Down's Syndrome

Assessment of Longitudinal Amyloid Load Change in Down Syndrome
Matthew Zammit, Charles Laymon, Karly Cody, Ann Cohen, Dana Tudorascu, Sterling Johnson, Tobey Betthauser, Todd Barnhart, Dhanabalan Murali, Charles Stone, Davneet Minhas, Shahid Zaman, William Klunk, Benjamin Handen, Brad Christian

Associations Between Aβ and Tau in Adults With Down Syndrome
Dana Tudorascu, Matthew Zammit, Karly Cody, Charles Laymon, Davneet Minhas, Paul Ellison, Shahid Zaman, Beau Ances, Sterling Johnson, Chester Mathis, William Klunk, Benjamin Handen, Bradley Christian, Ann Cohen

Spatial Associations of Aβ With Tau Deposition in Down Syndrome
Elijah Mak, Concepcion Padilla, Elizabeth Jones, Anastasia Bickerton, Madeleine Walpert, Young Hong, Tim Fryer, Jonathan Coles, Franklin Aigbirhio, Bradley Christian, Benjamin Handen, William Klunk, David Menon, Peter Nestor, Anthony Holland, Shahid Zaman

Sleep, Cognition, and β-Amyloid in Adults With Down Syndrome
Karly Cody, Brianna Piro-Gambetti, Matthew Zammit, Iulia Mihaila, Dana Tudorascu, Ann Cohen, Shahid Zaman, William Klunk, Barbara Bendlin, Sterling Johnson, Benjamin Handen, Brad Christian, Sigan Hartley

Baseline Amyloid (18F-AV-45 PET) Distributions by Consensus Diagnosis From the Biomarkers of Alzheimer’s Disease in Adults With Down Syndrome (ADDS) Consortium
David Keator, Julie Price, William Kreisl, Michael Phelan, Michael Yassa, Eric Doran, Christy Hom, Dana Nguyen, Florence Lai, Lisa Taylor, Margaret Pulsifer, H. Diana Rosas, Sharon Krinsky-McHale, Arit Banerjee, Adam Brickman, Nicole Schupf, Wayne Silverman, Ira Lott


4:15 - 4:30 p.m.

Break


4:30 - 4:45 p.m.

Presentation of the Neuroimaging Awards


4:45 - 5:45 p.m.

IC-07: Special Highlights at AAIC

Functional Brain Architecture Predicts Longitudinal Tau Spreading in Alzheimer’s Disease
Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Michael Ewers

What Can Structural MRI Tell About "a/T/N" Staging?
Alexander Lang, Michael Weiner, Duygu Tosun

Biomarkers for Capturing Amyloid Independent Effects of Vascular Health on Cognitive Decline
Prashanthi Vemuri, Scott Przybelski, Timothy Lesnick, Jonathan Graff-Radford, Mary Machulda, Robert Reid, Michelle Mielke, Val Lowe, Ashritha Reddy, Ronald Petersen, David Knopman, Clifford Jack

A Topographic Imaging Biomarker of TDP43 Pathology in Amnestic Dementia Based on Autopsy-Derived FDG-PET Patterns
Michel Grothe, Catharina Lange, Kwangsik Nho, Andrew Saykin, Irina Jelistratova, Peter Nelson, Ralph Buchert, Stefan Teipel

APOE Affect the Network Architecture of the Resting Brain in Individuals at Risk for AD
Patrizia Chiesa, Dimitris Trif, Olaf Sporns, Enrica Cavedo, Marie-Claude Potier, Simone Lista, Bruno Dubois, Harald Hampel


5:45 p.m.

Closing Remarks


6 - 7:30 p.m.

Reception
Intercontinental Los Angeles Downtown Hotel, Wilshire Grand 2-3


Target Audience

All clinicians involved in the care or research of individuals with memory or other cognitive complaints, including but not limited to neurologists, psychiatrists, radiologists, geriatricians, neuropsychologists, physicians and nurses; researchers, industry and regulatory agency stakeholders; and others involved in the use of imaging techniques in the study of Alzheimer’s disease, other dementias and normal aging.

Abstract Submission

The abstract submission process has closed.

Registration

AIC is a preconference to AAIC 2019. Preconferences come with separate registration fees in addition to AAIC full conference registration. Preconferences can also be purchased as stand-alone events. Registration for this preconference opened in February.

AIC Registration Fellowships

A limited number of fellowships, in the form of complimentary AIC registration, are available for early career scientists who are the presenting authors on an accepted abstract. Applications are accepted during the main abstract submission process for AIC, which has closed.

About ISTAART

ISTAART logo

The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) is a professional society for individuals interested in Alzheimer's and dementia science — including scientists, physicians and other professionals involved in the causes and treatments of Alzheimer's disease and other dementias.

ISTAART membership makes AAIC even better: Receive discounted registration, participate in Professional Interest Areas (PIAs), attend PIA Day scientific sessions before AAIC begins and get access to exclusive members-only scientific and networking events. Members also receive ongoing benefits throughout the year, including an online monthly subscription to Alzheimer's & Dementia®: The Journal of the Alzheimer's Association, free online access to Neurobiology of Aging, access to an online career center, monthly e-newsletters, networking forums and extended LOI deadlines for the Alzheimer's Association International Research Grant Program.

Learn more and join ISTAART online. Non-members can also join ISTAART during AAIC registration: Select “ISTAART Membership + AAIC Registration” as the AAIC registration category to purchase one year of ISTAART membership in addition to AAIC registration at the member rate.



Become an ISTAART Member

Members of this professional society stay connected to the field through exclusive member benefits and programs. Join for just $30* at the Alzheimer's Association (Booth 500).

*Offer available onsite at AAIC (through 7/18/19). Applies only to registrants who paid the non-member fee.

join today

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