Alzheimer's Imaging Consortium
Saturday, July 21, 2018
8 a.m. – 5:30 p.m.
McCormick Place, Room 183
The Alzheimer's Imaging Consortium (AIC), a preconference to the Alzheimer's Association International Conference (AAIC), will focus on the clinical application and methodological development of neuroimaging (MRI, PET, SPECT, CT and others) to Alzheimer's disease, other dementias and normal brain aging. The program consists of invited speakers, as well as oral and poster presentations from submitted abstracts.
The AIC is organized by the Neuroimaging Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment (ISTAART).
8 – 8:15 a.m.
Victor Villemagne, M.D.
Chair, Neuroimaging Professional Interest Area (NIPIA)
8:15 – 8:45 a.m.
Plenary Session: What Have We Learned?
David M. Cash, Ph.D.
University College London
8:45 – 10 a.m.
Oral Session: Tau Imaging
IC-02-01: The Relationship between Tau PET and Age across the Lifespan
IC-02-02: Discrepancies in Tau and β-Amyloid Burden Are Frequent across the Spectrum of Normal Aging and Alzheimer’s Disease
IC-02-03: Explaining [18f]-AV-1451 Variability in Healthy Controls across the Lifespan
IC-02-04: Regional Asymmetries in Amyloid and Tau Go Together: Evidence for Local Interaction
IC-02-05: The Influence of Age on Regional [18f]AV-1451 PET, Pittsburgh Compound B PET and MRI Atrophy in Atypical Alzheimer’s Disease
10 – 10:15 a.m.
10:15 – 10:45 a.m.
Data Blitz Presentations (Five presentations at three minutes each)
DB-01-01: Advanced Diffusion MRI Enables In Vivo Investigation of Microstructural Heterogeneity of White Matter Hyperintensities in Alzheimer’s Disease
DB-01-02: Genetic and Environmental Factors Are Differentially Related to Aβ Burden in the Presymptomatic Phase of Autosomal Dominant and Sporadic Alzheimer’s Disease
DB-01-03: Multivariate Pattern Analysis on a Longitudinal Cohort of Cognitively Normal Elderly Reveals Distinct Stages of Regional Amyloid Deposition
DB-01-04: Non-Amnestic Phenotypes of Alzheimer’s Disease, Early Age of Onset and Apoe Genotype Are Associated with Tau-, Not Aβ-PET
Renaud La Joie
DB-01-05: Longitudinal Accumulation of β-Amyloid on PET in Dementia with Lewy Bodies and Relationship to Clinical Disease Progression
10:45 – 11:15 a.m.
Plenary Session: Imaging of Synaptic Density in the Human Brain
Richard E. Carson, Ph.D.
New Haven, Connecticut, United States
11:15 a.m. – 12:30 p.m.
Integrative Molecular and New Imaging Modalities in Neurodegeneration
IC-04-01: A Precision Medicine Approach to Modeling Biomarkers in Early and Late Onset Alzheimer’s Disease
IC-04-02: Serum Neurofilament Light Chain Levels Are Associated with Cortical Thickness, Beta-Amyloid Burden, and Cerebral Glucose Metabolism in Autosomal Dominant Alzheimer Disease
IC-04-03: PET Imaging of Metabotropic Glutamate Receptor 5 Binding in Alzheimer’s Disease
IC-04-04: Neuroinflammation and 18f-AV-1451 PET Findings in Semantic Dementia
IC-04-05: Imaging Epigenetics in the Human Brain with the Novel [11c]Martinostat PET in Preclinical AD, MCI, AD, and Frontotemporal Dementia Individuals
12:30 – 1:45 p.m.
Lunch & Poster Viewing
1:45 – 2:45 p.m.
Debate Session: CSF vs. Imaging Biomarkers
Philip Scheltens, M.D., Ph.D.
Alzheimer center, VU University Medical Center
Amsterdam, the Netherlands
Henrik Zetterberg, M.D., Ph.D.
University of Gothenburg, Sweden;
University College London, London, England;
Sahlgrenska Academy at the University of Gothenburg, Sweden
2:45 – 4 p.m.
Oral Session: MRI
IC-06-01: Quantitative Sodium MRI Is More Sensitive Than Volumetry for Differentiating between Mild Cognitive Impairment and Cognitively Normal Older Adults
IC-06-02: Non-Invasive Imaging of Brain Clearance Pathways Using Multiple Echo Time Arterial Spin Labelling: An Aquaporin-4 Study
IC-06-03: Distinct Longitudinal Cortical Atrophy in Non-Amnestic Compared to Amnestic Alzheimer's Disease Suggests Different Patterns of Spreading Pathology
Fulvio Da Re
IC-06-04: Antemortem Longitudinal MRI Metrics As a Biomarker of Postmortem Braak NFT Staging
IC-06-05: Loss of Grey Matter Connectivity in the Precuneus Is Associated with Faster Atrophy Rates in Preclinical Alzheimer’s Disease.
4 – 4:15 p.m.
4:15 – 4:30 p.m.
Presentation of the Neuroimaging Awards
4:30 – 5:15 p.m.
Coming Attractions at AAIC
IC-07-01: Entorhinal Cortex Tau PET, Cortical Thickness and Memory Performance in Cognitively Unimpaired Persons
IC-07-02: Longitudinal Tau-PET and Atrophy in Healthy Older Adults and Alzheimer’s Disease
IC-07-03: A Polygenic AD Risk Score Predicts Amyloid Accumulation over a 6-Year Interval in Cognitively Intact Older Adults.
IC-07-04: Early Increase in Tau-PET Signal Is Associated with Aβ Burden, CSF p-Tau Levels and Cognition in Cognitively Normal Late-Middle-Aged Adults
Chair, Neuroimaging Professional Interest Area (NIPIA)
5:30 – 7 p.m.
Location: Marriott Marquis, Great Lakes D-G
All clinicians involved in the care or research of individuals with memory or other cognitive complaints, including but not limited to neurologists, psychiatrists, radiologists, geriatricians, neuropsychologists, physicians and nurses; researchers, industry and regulatory agency stakeholders; and others involved in the use of imaging techniques in the study of Alzheimer’s disease, related disorders and normal aging.
AIC is a preconference to AAIC 2018. Preconferences require a separate registration fee in addition to AAIC full conference registration or it may be purchased as a stand-alone event. Registration is open.
A limited number of fellowships, in the form of complimentary AIC registration, are available for early career scientists who are the presenting author on an accepted abstract. Applications are accepted during the main abstract submission process.
The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) is a professional society for individuals interested in Alzheimer's and dementia science—including scientists, physicians and other professionals involved in the causes and treatments of Alzheimer's disease and other dementias. ISTAART membership makes AAIC even better: receive discounted registration, participate in professional interest areas (PIA), attend PIA Day scientific sessions (Saturday, July 21) and attend exclusive member-only scientific and networking events. Members also receive ongoing benefits throughout the year, including an online monthly subscription to Alzheimer's & Dementia: The Journal of the Alzheimer's Association, free online access to Neurobiology of Aging, access to the online career center, monthly e-newsletters, networking forums and extended LOI deadlines for the Alzheimer's Association International Research Grant Program.
Non-members are encouraged to learn more and join ISTAART. Non-members may also join ISTAART during AAIC registration -- select "Member +PLUS" or "Student Member +PLUS " as the AAIC registration category to purchase one year of ISTAART membership in addition to AAIC registration at the member rate. Available to new members only.