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Educational Workshop: Focus on Statistics — Understanding Novel Models for Repeated Measures of Continuous Outcomes Including Cognitive Function

Friday, July 24, 2020
8 a.m. – 5 p.m.
Amsterdam, Netherlands


This course’s main goal is to provide researchers and health professionals with a practical review of advanced analytical methods commonly in scientific articles to model change of continuous outcomes (i.e. cognitive scores, some measure of physical function) over time. This applied workshop will use real data examples to review advanced modern methods used to evaluate the change in cognition over time. These models are used to ascertain:

  1. Linear change over time depending on predictors at baseline and time-varying.
  2. Linear change over time before and after a known event (i.e. new medication intake or diagnosis of a condition that may be associated with the function of interest).
  3. The onset of accelerated change (i.e. fixed and random change point models commonly used to study terminal decline).
  4. Half-decline of nonlinear curves through the sigmoidal model (such as the sigmoidal curves postulated in Jack’s model).
  5. The shape of the trajectory using sigmoidal model and other strategies.

Each module will include the discussion of the concepts and analytical models and their limitations and data requirements and will also include a demonstration of code and output interpretation. The material will be distributed to all participants with annotated code.

Good working knowledge of multiple regression models is required.

This workshop is organized by the ISTAART Design and Data Analytics Professional Interest Area.

Organizing Committee


  • Time
  • Topics

8 a.m.

Opening Remarks
Ana W. Capuano, RADC, Rush University Medical Center
Graciela Muniz-Terrera, University of Edinburgh

8:10 a.m.

Longitudinal Data in Global Cognition and Sample Data
Ana W. Capuano, RADC, Rush University Medical Center

8:40 a.m.

Linear Mixed Effects Models and Time-varying Predictors
Donald Hedeker, University of Chicago

10:40 a.m.


10:55 a.m.

Fixed Change-point Models
Graciela Muniz-Terrera, University of Edinburgh


Lunch (included with registration fee)

1 p.m.

Random Change-point Models (Abrupt and Smooth Change Point)
Graciela Muniz-Terrera, University of Edinburgh

2 p.m.


2:15 p.m.

Smooth Nonlinear Models (Sigmoidal Model and Others)
Ana W. Capuano, RADC, Rush University Medical Center

4:15 p.m.

Modeling Change in Variance
Donald Hedeker, University of Chicago

4:50 p.m.

Closing Remarks

Target Audience

This workshop can serve as a beginners or refresher course for established investigators, clinicians and trainees.


Educational workshops come with separate registration fees in addition to AAIC full conference registration. Workshops can also be purchased as stand-alone events. Visit the Registration page.


ISTAART logoThe Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) is a professional society for individuals interested in Alzheimer's and dementia science — including scientists, physicians and other professionals involved in the causes and treatments of Alzheimer's disease and other dementias.

ISTAART membership makes AAIC even better: Receive discounted registration, participate in Professional Interest Areas (PIAs), attend PIA Day scientific sessions before AAIC begins and get access to exclusive members-only scientific and networking events. Members also receive ongoing benefits throughout the year, including an online monthly subscription to Alzheimer's & Dementia®: The Journal of the Alzheimer's Association, free online access to Neurobiology of Aging, access to an online career center, monthly e-newsletters, networking forums and extended LOI deadlines for the Alzheimer's Association International Research Grant Program.

Learn more and join ISTAART. New members can also join ISTAART during AAIC registration: Select “ISTAART Membership + AAIC Registration” as the AAIC registration category to purchase one year of ISTAART membership in addition to AAIC registration at the member rate.

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