Two lifestyle interventions in U.S. POINTER improved cognition in older adults at risk of cognitive decline. The cognitive benefits were even greater for participants in the more structured intervention group, helping to protect thinking and memory from the normal decline that often comes with aging over the nearly two-year period of the study. Read the study results.
The Alzheimer's Association U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline. U.S. POINTER is the first large-scale, randomized controlled clinical trial to demonstrate that an accessible and sustainable healthy lifestyle intervention — a combination of diet, exercise, heart health, and cognitive challenge and social engagement — can protect cognitive function in diverse populations in communities across the United States.
Read about U.S. POINTER study leadership and our principal investigators.
Find out about the largest multidomain lifestyle intervention trial for the prevention of cognitive decline.
Learn how lifestyle interventions targeting multiple risk factors improved cognition in older adults at risk of cognitive decline.
In 2014, a large-scale two-year study in Finland in healthy older adults at increased risk of cognitive decline and dementia (the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, or FINGER Study) reported that a two-year combination therapy simultaneously targeting physical exercise, a healthy diet, cognitive stimulation, and self-monitoring of heart health risk factors had a protective effect on cognitive function. FINGER and U.S. POINTER join other similar efforts around the globe in a worldwide consortium, World Wide FINGERS (WW-FINGERS). WW-FINGERS will align these research efforts focused on the prevention of cognitive decline, including possibly Alzheimer's disease and other dementias across the globe.
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