In just 15 months, Mikey Hoag and the Part the Cloud committee and gala, have been able to generate $2 million in funding for Alzheimer’s research – a remarkable effort that will have a true impact on moving critical studies forward to achieve potential therapies. These awards are designed to accelerate transition of findings from the laboratory, through trials, into possible therapies – filling the gap in Alzheimer’s drug development by providing essential support for early phase clinical studies. Due to this increase in funding, the Alzheimer’s Association has awarded five research awards since January 2013 as a result. These awards span a variety of targets in Alzheimer’s disease research and fall under the leadership of some of the nation's most prestigious scientists and universities:
Adam L. Boxer, M.D, Ph.D., University of California, San Francisco
Title: Phase I Multiple Ascending Dose Trial of the MT Stabilizer TPI-287 for AD
Dr. Boxer and his team are working to moderate the stability of microtubules — small, tube-like structures that act like a skeleton inside cells, maintain cell structure and help to transport nutrients throughout the cell —potentially decreasing the abnormal buildup of tau protein into tangles, one of the hallmark brain changes of Alzheimer’s disease.
Frank Longo, M.D., Stanford University and Anne Longo, Pharmatrophix, Inc.
Title: Phase I Trial for P75 Receptor Ligand
This study aims to test a therapy that targets the cell death pathway associated with Alzheimer’s disease
by inhibiting a known component. The researchers hope to ultimately determine whether this decreases
the detrimental effects of Alzheimer’s in the brain.
Ahmad Salehi, M.D., Ph.D., Palo Alto Institute for Research & Education, Inc.
Title: Improving ß2 Adrenergic Signaling in Alzheimer’s Disease
Researchers at the Palo Alto Institute for Research & Education, Inc., are exploring potential
therapeutics to improve the health of brain connections thought to play an early role in the disease
Dale E. Bredesen, M.D., Buck Institute for Research on Aging
Title: An Exploratory Safety, PK/PD, and Preliminary Efficacy Study of F03 in MCI
This study strives to impact the activity level of Amyloid Precursor Protein (APP), the complex
responsible for the production of the beta amyloid — thereby potentially influencing the amount of beta
amyloid produced in the brain.
Keith Vossel, M.D., University of California, San Francisco and Gladstone Institute for Neurological
Title: Phase 2a Levetiracetam Trial for AD-Associated Network Hyperexcitability
Led by Dr. Keith Vossel, these scientists are working to moderate the amount of underlying electrical
activity of the brain cells associated with Alzheimer’s disease to potentially impact the rate an
individuals’ cognition declines.
The Part the Cloud initiative also supported, in part, Mike Weiner, MD (principal investigator of ADNI) and the Whole Genome Sequencing Alzheimer’s Disease Neuroimaging Initiative (WGS-ADNI), a project to sequence the whole genome of more than 800 individuals. The genome data will be available to researchers around the world this summer, enabling further study of the genes related to Alzheimer’s.