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How does gender impact the link between traumatic brain injury and risk of developing dementia?
Tatyana Mollayeva, M.D., Ph.D.
Trinity College Dublin, Ireland
Dublin, Ireland
Background
Studies have shown a link between traumatic brain injury (TBI) and an increase in one’s risk of developing cognitive impairment and dementia later in life. However, the exact biological mechanisms for this link remain largely unknown. Further, the impact of additional factors such as sex and gender on an individuals risk for getting a TBI and its impact on an individual’s lifetime risk of cognitive decline and dementia have not been evaluated.
Research Plan
Dr. Tatyana Mollayeva and colleagues aim to understand the link between TBI and sex and gender using healthcare records from over 80,000 individuals in a population-based study. They will first focus on social and environmental factors associated with TBI in both males and females. Next, the team will examine how these factors may influence the prevalence and risk of TBI. Further, they will evaluate if there are differences or similarities of the impact of TBI on an individual’s lifetime risk for cognitive impairment or dementia between genders.
Impact
Dr. Mollayeva’s project could refine our understanding of TBI and dementia risk in the U.S.. It could also provide key insight into better understanding an individual’s risk factor for developing dementia.
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