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2019 Pilot Awards for Global Brain Health Leaders (GBHI)

Gut microbiome restoration in elders with HIV-associated cognitive disorder

Luis Arnoldo Munoz Nevarez, MD
Global Brain Health Institute and Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara, Mexico

Dr. Munoz Nevarez plans to determine the efficacy and safety of probiotic supplements as a therapeutic approach for older individuals (greater than 50 years) living with HIV who experience cognitive impairment. HIV infection produces an inflammatory change in the gut microbiome that could in turn contribute to brain inflammation. The study participants will be recruited from a university-affiliated medical center in Mexico and divided into two groups – one that takes the probiotic supplement, and another that does not. Dr. Munoz Nevarez plans to evaluate the impact of probiotics on the gut microbiome in these participants. The study results will provide new insights into links of gut and brain axis in individuals living and aging with HIV infection, as well as help to distribute knowledge to advance the field of brain health and dementia prevention.

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