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2019 GAAIN Exploration to Evaluate Novel Alzheimer's Queries (GEENA-Q)

Identification of drug-disease Interaction in AD patients from GAAIN

Feng Cheng, Ph.D.
University of South Florida
Tampa, FL - United States

Drug-disease interaction is an important and relevant topic for individuals with Alzheimer’s.  When prescribing medication, different factors such as duration of the use, dose of medication, timing of the dosage, how the drug travels through the body etc. along with biological processes associated with aging in individuals, are taken into consideration.  Dr. Feng Cheng proposes to develop statistical models, to identify possible drug-disease interactions to help inform considerations of medications for individuals with Alzheimer’s.  Dr. Cheng proposes to focus on the following research questions to achieve this goal: first, Dr. Cheng will identify drug combinations that are associated with cognitive performance based on data collected from the (Global Alzheimer’s Association Interactive Network) GAAIN platform; second, the team will  focus on demographic factors that are relevant in these drug-disease interactions by using demographic data from the Food and Drug Administration Adverse Event Reporting System database.  If successful, the project results may provide information for clinicians to consider safer and alternative drugs for individuals with Alzheimer’s.

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