Dr. Lemere received her B.A. degree in psychology and education from Mount Holyoke College, her M.S. degree in neurobiology from the State University of New York at Albany and her Ph.D. in pathology from Boston University School of Medicine.
She began working as a research technician at the Center for Neurologic Diseases (CND) in the Department of Neurology at Brigham and Women's Hospital 18 years ago. A year later, she began pursuing her Ph.D. and conducted research on the temporal pathogenesis of Alzheimer's disease in people with Down syndrome and APP transgenic mice in the laboratory of Dr. Dennis Selkoe.
Once she completed her degree, she remained at the CND as a post-doctoral fellow and instructor, studying human brain samples from patients with presenilin 1 mutations from a large family in Medellin, Colombia.
Over the past eight years, much of her work has focused on developing a safe and effective amyloid-beta vaccine for the prevention or treatment of Alzheimer's disease. Her studies rely on examination of the humoral and cellular immune response as well as pathological and cognitive changes as the consequence of such vaccines in animal models.
In addition, Dr. Lemere's lab studies the role of complement protein C3 in Alzheimer's disease pathogenesis and amyloid-beta clearance in the human brain and in mouse models of Alzheimer's disease.
Lastly, in collaboration with colleagues at Peking Union Medical College, her lab is investigating the effects of L-NBP, a synthetic compound based upon an extract from Chinese celery seed, on memory and Alzheimer’s pathogenesis in mouse models of Alzheimer's disease.