The Part the Cloud (PTC) challenge on inflammation will accelerate therapeutics and discovery of innovative compounds to be used in early clinical trials.
Inflammation in the brain is part of the neurodegeneration process, but the role it plays is enigmatic. Simultaneously, the immune system in the brain seems to be both injurious as well as beneficial. There is a great need for better understanding in this area. Only recently have we discovered that cells involved in inflammation originate both from within the brain and from peripheral blood cells that migrate to the brain. Most importantly, several genes linked to immune cell function have been identified that increase the risk for neurodegeneration, but little is also known about their function. Finally, there is evidence that external factors like systemic inflammation, the microbiome and obesity can influence the immune response within the brain. The challenge is to understand these processes in a way that leads to drug development in order to ameliorate the detrimental effects or redirect them for beneficial outcomes.
Earlier attempts at anti-inflammatory therapies in AD were disappointing, but in retrospect, those early approaches were uninformed by the many significant advances that have been made in the past decade. The PTC challenge on neuroinflammation will directly support the development of new therapeutic strategies and advance these compounds into human clinical trials.
The Sex and Gender in Alzheimer's (SAGA) request for applications aims to support scientific investigation into the contributions of sex-related biological, genetic and lifestyle to the pathophysiology of Alzheimer’s and related dementias.
Potential themes may include but not be limited to investigations that:
- Studies to investigate biological sex differences in aging and AD, including link of hormone, telomeres and other aging-related factors
- Studies of genetic links with APOEe4, X chromosome and other genes, including biological mechanism(s) of action, implications for disease pathogenesis
- Understanding sexual dimorphism in brain function, as it relates to vulnerability for AD and related dementias
- Investigating links between hormone levels (i.e. perimenopause) and energy metabolisms (i.e. shift from glucose to ketone energy usage) for disease pathogenesis
- Investigating the biological sex contributions to brain networks, pathology and link to clinical phenotypes of AD and related dementias
- Understanding various lifestyle factors (i.e. stress, vascular and metabolic contributions, sleep, depression) impact neurobiological context on vulnerability for AD and related dementias
- Investigating stress response differences between male/ female and impact on disease vulnerability as well as ways to ameliorate stress-related impact
CLOSED: New Investigator Research Grant (NIRG)
Funds the next generation of promising scientists who have earned their doctoral degrees within the last 10 years.
CLOSED: New Investigator Research Grant to Promote Diversity (NIRGD)
Funds new investigators from diverse backgrounds with intent to support early career development that will lay groundwork for future research grants.
CLOSED: Mentored New Investigator Research Grant to Promote Diversity (MNIRGD)
Funds mentored research conducted by underrepresented researchers who have earned their doctoral degrees within the last 10 years.
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